Results 21 to 30 of about 4,080,754 (294)

Targeting Liver Sinusoidal Endothelial Cells: An Attractive Therapeutic Strategy to Control Inflammation in Nonalcoholic Fatty Liver Disease

Frontiers in Pharmacology, 2021
Nonalcoholic fatty liver disease (NAFLD), especially its advanced stage nonalcoholic steatohepatitis (NASH), has become a threatened public health problem worldwide. However, no specific drug has been approved for clinical use to treat patients with NASH,
Xue-Kai Wang, Zong-Gen Peng, Zong-Gen Peng, Zong-Gen Peng   +3 more
doaj   +1 more source

Antiviral agents for the treatment of COVID-19: Progress and challenges

Cell Reports Medicine, 2022
The COVID-19 pandemic has seen clinical development and use of antiviral therapies at an unprecedented speed. Antiviral therapies have greatly improved the clinical outcome in COVID-19 patients, especially when administered early after diagnosis.
Manmeet Singh, E. de Wit
semanticscholar   +1 more source

Efficacy decrease of antiviral agents when administered to ongoing hepatitis C virus infections in cell culture

Frontiers in Microbiology, 2022
We report a quantification of the decrease of effectiveness of antiviral agents directed to hepatitis C virus, when the agents are added during an ongoing infection in cell culture vs. when they are added at the beginning of the infection.
Carlos García-Crespo, Carlos García-Crespo, Lucía Vázquez-Sirvent, Lucía Vázquez-Sirvent, Pilar Somovilla, Pilar Somovilla, María Eugenia Soria, María Eugenia Soria, María Eugenia Soria, Isabel Gallego, Isabel Gallego, Ana Isabel de Ávila, Ana Isabel de Ávila, Brenda Martínez-González, Brenda Martínez-González, Antoni Durán-Pastor, Esteban Domingo, Esteban Domingo, Celia Perales, Celia Perales, Celia Perales, Celia Perales   +21 more
doaj   +1 more source

Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview

Pharmaceuticals, 2021
To date, the leading causes of mortality and morbidity worldwide include viral infections, such as Ebola, influenza virus, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) and recently COVID-19 disease, caused by the ...
T. Behl, G. Rocchetti, Swati Chadha, G. Zengin, S. Bungău, Arun Kumar, Vineet Mehta, Md Elias Uddin, Gaurav Khullar, Dhruv Setia, S. Arora, Kouadio Ibrahime Sinan, Gunes Ak, P. Putnik, M. Gallo, D. Montesano   +15 more
semanticscholar   +1 more source

Incidence of acute kidney injury (AKI) and outcomes in COVID-19 patients with and without antiviral medications: A retrospective study.

PLoS ONE, 2023
BackgroundAcute kidney injury is a complication of COVID-19 and is associated with severity. Despite no specific antiviral treatment strategy, lopinavir/ritonavir and remdesivir have been used.
Seyed Majid Mousavi Movahed, Hamed Akhavizadegan, Fatemeh Dolatkhani, Samaneh Akbarpour, Seyed Aria Nejadghaderi, Morvarid Najafi, Parmida Sadat Pezeshki, Akram Khalili Noushabadi, Hoomaan Ghasemi   +8 more
doaj   +1 more source

Synthetic and medicinal perspective of quinolines as antiviral agents

European journal of medicinal chemistry, 2021
In current scenario, various heterocycles have come up exhibiting crucial role in various medicinal agents which are valuable for mankind. Out of diverse range of heterocycle, quinoline scaffold have been proved to play an important role in broad range ...
R. Kaur, Kapil Kumar
semanticscholar   +1 more source

Isatin derivatives as broad-spectrum antiviral agents: the current landscape

Medicinal Chemistry Research, 2022
In recent decades, several viruses have resulted in large outbreaks with serious health, economic and social consequences. The current unprecedented outbreak of the new coronavirus, SARS-COV-2, necessitates intensive efforts for delivering effective ...
T. Elsaman, M. Mohamed, E. Eltayib, H. Abdel‐Aziz, A. E. Abdalla, Muhammad Usman Munir, M. A. Mohamed   +6 more
semanticscholar   +1 more source

Broad-spectrum antiviral agents

Frontiers in Microbiology, 2015
Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular ...
Jun-Da eZhu, Wen eMeng, Xiao-Jia eWang, Hwa-Chain Robert Wang   +3 more
doaj   +1 more source

Antiviral Agents: Discovery to Resistance

Viruses, 2020
In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
Catherine S. Adamson
doaj   +1 more source

Antiviral Agents

Medical Clinics of North America, 1988
Potent effective antiviral drugs recently have been licensed for several viral diseases, ushering in a new era in the treatment of viral diseases. Several unique features in the process of a viral infection have been identified as target points for inhibition. The unique steps and the interfering compounds are the subject of this review.
Reines, Eric D., Gross, Peter A.
openaire   +2 more sources