Results 51 to 60 of about 3,598,763 (344)
Effect of antiviral therapy in reducing perinatal transmission of hepatitis B virus and maternal outcomes after discontinuing them [PDF]
Clinical and Molecular Hepatology, 2018 Background/Aims There have been numerous efforts to reduce mother-to-child transmission (MTCT) of hepatitis B virus (HBV) with antiviral agents during pregnancy.
Kwang Il Seo +21 more
doaj +1 more source
Graphene‐Based Nanocomposites as Antibacterial, Antiviral and Antifungal Agents
Advanced Healthcare Materials, 2022 Over the past decade, there have been many interesting studies in the scientific literature about the interaction of graphene‐based polymeric nanocomposites with microorganisms to tackle antimicrobial resistance.
Seda Gungordu Er +2 more
semanticscholar +1 more source
Acta Pharmaceutica Sinica BThe pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs with broad-spectrum antiviral activity. Here, we show that carrimycin, a new macrolide antibiotic in the clinic and an antiviral candidate
Hongying Li +17 more
doaj +1 more source
Progression of Antiviral Agents Targeting Viral Polymerases
Molecules, 2022 Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize the genetic materials of the virus itself, and they have become extremely favorable targets for the development of antiviral drugs because of their relatively conserved
Siqi Peng +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Silver nanoparticles as potential antiviral agents against African swine fever virus
Materials Research Express, 2020 African swine fever virus (ASFV) is the cause of a highly contagious and fatal disease in domestic swine, but no vaccine or effective medicine is available so far, therefore, looking for a novel and effective anti-ASFV agent is a very imperative mission.
Tran Thi Ngoc Dung +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
BMC Infectious Diseases, 2022 Background In HCV-infected patients with advanced liver disease, the direct antiviral agents-associated clinical benefits remain debated. We compared the clinical outcome of patients with a previous history of decompensated cirrhosis following treatment ...
Georges-Philippe Pageaux +37 more
doaj +1 more source
Sulfonamides with Heterocyclic Periphery as Antiviral Agents
Molecules, 2022 Sulfonamides are the basic motifs for a whole generation of drugs from a large group of antibiotics. Currently, research in the field of the new sulfonamide synthesis has received a “second wind”, due to the increase in the synthetic capabilities of ...
Mikhail Yu. Moskalik
doaj +1 more source