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, 2009 Antiviral agents are drugs approved in the USA by the Food and Drug Administration (FDA) for the treatment or control of viral infections. Available antiviral agents mainly target stages in the viral life cycle. The target stages in the viral life cycle are; viral attachment to host cell, uncoating, synthesis of viral mRNA, translation of mRNA ...
Paintsil, E., Cheng, Yung-Chi
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‘Tomato Flu’ – An outbreak in India with particular emphasis on antiviral therapy [PDF]
Infectious Diseases and Tropical Medicine, 2022 Recently, some Indian states reported an outbreak of a ‘mysterious illness’ involving more than a hundred children younger than nine years, with fever and skin lesions.
I. Asra +5 more
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Polyclonal and monoclonal B lymphocytes response in HCV-infected patients treated with direct-acting antiviral agents [PDF]
, 2017 Hepatitis C virus (HCV) chronic infection can be associated with extrahepatic manifestations such as mixed cryoglobulinaemia and lymphoproliferative disorders that are endowed with increased rates of morbidity and all-cause mortality.
Burra, Patrizia +13 more
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Progress with antiviral agents [PDF]
FEBS Letters, 1974 It is perhaps pretentious to employ the current popular term ‘antiviral chemotherapy’ when only three classes of compounds are officially approved for limited clinical application: N-methylisatin3i adamantamine, for prophylaxis in humans subject to influenza A-2 virus infections [2,3] ; and 5iodo-2’-deoxyuridine (IUdR) for therapy of herpes simplex ...
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Antibiotics, 2023 The development of potent antiviral agents is of utmost importance to combat the global burden of viral infections. Traditional antiviral drug development involves targeting specific viral proteins, which may lead to the emergence of resistant strains ...
Umme Laila Urmi +6 more
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Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents [PDF]
, 2014 Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes.
A Owsianka +72 more
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Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]
, 2020 On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P. +4 more
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Medicinal chemistry strategies toward host targeting antiviral agents
Medicinal research reviews (Print), 2020 Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic.
Xingyue Ji, Zhuorong Li
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Viruses, 2020 The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options. In this study, we investigated the anti-SARS-CoV-2 activities of
Shuofeng Yuan +15 more
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Polysaccharides as antiviral agents: antiviral activity of carrageenan [PDF]
Antimicrobial Agents and Chemotherapy, 1987 A number of polysaccharides showed good antiviral activity against several animal viruses. At 5 micrograms/ml, carrageenan prevented the cell monolayer from destruction by herpes simplex virus type 1 (HSV-1) growth. At 10 micrograms/ml, carrageenan reduced the formation of new infectious HSV-1 by almost five logs.
González, M. E. +2 more
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