Results 121 to 130 of about 70,871 (236)

Antiviral Defenses [PDF]

, 2014
openaire   +1 more source

Active Learning for the Discovery of Antiviral Polymers

Macromolecular Rapid Communications, EarlyView.
Machine learning and active learning are integrated to accelerate the discovery of antiviral polymers. Molecular descriptors derived from polymer composition enable predictive modeling of antiviral activity, while unsupervised clustering explores chemical diversity. The active learning workflow identifies optimal candidates for synthesis, demonstrating
Clodagh M Boland, Nhat Quynh Nguyen, Nathan RB Boase   +2 more
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Far-red light orchestrates antiviral defense in plants. [PDF]

Sci Adv
Gong Q, He L, Huang F, Wang Y, Xie J, Hong Y, Liu Y.   +6 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi. [PDF]

mLife
Du Y, Jiang D, Liu H.
europepmc   +1 more source

Demystifying fungal systematics: A gateway to fungal literacy and societal/ecological relevance through familiar species

PLANTS, PEOPLE, PLANET, EarlyView.
Fungal systematics can feel overwhelming given the vast species diversity within this kingdom, with numerous subgroups at every taxonomic rank. This often creates a disconnect between the undertsnidng of fungal taxonomic diversity and their societal relevance.
Anna Vaiana, Francis Martin, Rasmus Kjøller, Toby Spribille, Garima Singh   +4 more
wiley   +1 more source

Opn3 Drives Blue-Light-Induced Reduction in Lipid Droplets and Antiviral Defense. [PDF]

Biomolecules
Wu Q, Liu H, Liang H, Jiang X, Qin Y, Liang S, Wang J, Liu K.   +7 more
europepmc   +1 more source

TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. [PDF]

Sci Adv, 2023
Fruhwürth S, Reinert LS, Öberg C, Sakr M, Henricsson M, Zetterberg H, Paludan SR.   +6 more
europepmc   +1 more source