Results 221 to 230 of about 70,871 (236)

Effector-triggered immunity in mammalian antiviral defense

Trends in Immunology, 2022
Effector-triggered immunity (ETI) is a common defense strategy used by mammalian host cells that is engaged upon detection of the enzymatic activities of pathogen-encoded proteins or the effects of their expression on cellular homeostasis. However, in contrast to the effector-triggered responses engaged upon bacterial infection, much less is understood
Megan H. Orzalli, Pooja Parameswaran
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Antiviral Activities of Human Host Defense Peptides

Current Medicinal Chemistry, 2020
Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common structural features, including an amphipathic structure and cationic charge, they have been widely ...
David C, Brice, Gill, Diamond
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Emerging antiviral defense systems in fungi

Cell Host & Microbe
In this issue of Cell Host & Microbe, Honda et al. identify an antiviral defense system in fungi. Mycoviruses trigger the expression of RNA-editing enzymes, which catalyze the editing of mRNAs encoding zinc finger transcription factors. This system differs from the RNA interference and is conserved in filamentous fungi.
Zeyu, Duan, Xiao, Liu
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Antiviral defense in plant stem cells

Trends in Plant Science
Undifferentiated plant and animal stem cells are essential for cell, tissue, and organ differentiation, development, and growth. They possess unusual antiviral immunity which differs from that in specialized cells. By comparison to animal stem cells, we discuss how plant stem cells defend against viral invasion and beyond.
Jie Li, Elizabeth Hong, Pengcheng Zhang, Mahmut Tör, Jianjun Zhao, Stephen Jackson, Yiguo Hong   +6 more
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RNA silencing and antiviral defense in plants

Current Opinion in Plant Biology, 2005
Much progress has been made recently in identifying the molecular components of RNA silencing in plants, and in understanding their roles in the biogenesis of small interfering RNAs and microRNAs, in RNA-directed DNA methylation, and in RNA-mediated antiviral defense. However, many crucial questions remain unanswered.
Ming-Bo, Wang, Michael, Metzlaff
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Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense

Journal of Genetics and Genomics, 2018
Viruses can infect host plants to cause severe diseases and substantial agricultural loss, while plants have evolved RNA interference (RNAi) strategy to defend against viral infection. Despite enormous efforts, only a few host proteins in RNAi pathway were shown to mediate antiviral defense, including RNA-dependent RNA polymerase 1 (RDR1), RDR6, DICER ...
Hua, Gao, Mai, Yang, Haitao, Yang, Yue, Qin, Biyun, Zhu, Gang, Xu, Chengyuan, Xie, Dewei, Wu, Xiaolin, Zhang, Wanxiang, Li, Jianbin, Yan, Susheng, Song, Tiancong, Qi, Shou-Wei, Ding, Daoxin, Xie   +14 more
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RNA interference: antiviral defense and genetic tool

Nature Immunology, 2002
Higher eukaryotes can mount antiviral immune responses induced by dsRNA. This process, called RNA interference, is sequence specific and can therefore be used to target gene expression.
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Dendritic cells and antiviral defenses

2010
The goal of our research is to identify new molecular pathways regulating the biology of DC subsets or more generally innate immune responses to viral infection. The model used is murine cytomegalovirus (MCMV) infection. The specific aims are 1) to determine the molecular bases regulating in vivo differentiation and anti-viral functions of DC subsets ...
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Crop antiviral defense: Past and future perspective

Science China Life Sciences
Viral pathogens not only threaten the health and life of humans and animals but also cause enormous crop yield losses and contribute to global food insecurity. To defend against viral pathogens, plants have evolved an intricate immune system to perceive and cope with such attacks.
Zhirui, Yang, Guangyao, Li, Yongliang, Zhang, Fangfang, Li, Tao, Zhou, Jian, Ye, Xianbing, Wang, Xiaoming, Zhang, Zongtao, Sun, Xiaorong, Tao, Ming, Wu, Jianguo, Wu, Yi, Li   +12 more
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Editorial overview: Evolution of antiviral defense

Current Opinion in Microbiology, 2023
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