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Antiviral Activities of Human Host Defense Peptides
Current Medicinal Chemistry, 2020Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common structural features, including an amphipathic structure and cationic charge, they have been widely ...
Gill Diamond, David C Brice
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Autophagy and antiviral defense
IUBMB Life, 2021AbstractTargeting intracellular components for lysosomal degradation by autophagy not only maintains cellular homeostasis but also counteracts the effects of external stimuli, including invading pathogens. Among various kinds of pathogens, viruses have been extensively shown to induce autophagy to benefit viral growth in infected cells and to modulate ...
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Neutrophils and antiviral defense
The Pediatric Infectious Disease Journal, 1986Revue des interactions entre neutrophiles et virus. Ces etudes in vitro ont mis en evidence une reaction cytotoxique a mediation neutrophile vis-a-vis des cellules infectees par virus en presence d'anticorps seul, ou de complement seul.
H, Faden, P, Ogra
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Bacterial multicellular behavior in antiviral defense
Current Opinion in Microbiology, 2023Multicellular behaviour benefits seemingly simple organisms such as bacteria, by improving nutrient uptake, resistance to stresses or by providing advantages in predatory interactions. Several recent studies have shown that this also extends to the defense against bacteriophages, which are omnipresent in almost all habitats.
Luthe, Tom +3 more
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Interferon-independent antiviral defense
Science, 2017Immunology Antiviral responses are normally initiated by interferon production, which stimulates the phosphorylation and activation of STAT1 and STAT2. These transcription factors, in complex with the transcriptional regulator IRF9, mediate antiviral gene expression. Wang et al.
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Hippo-sized antiviral defenses
Science Signaling, 2017The Hippo signaling pathway modulates the strength of antiviral responses according to nutritional status or cell density.
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RNA silencing and antiviral defense in plants
Current Opinion in Plant Biology, 2005Much progress has been made recently in identifying the molecular components of RNA silencing in plants, and in understanding their roles in the biogenesis of small interfering RNAs and microRNAs, in RNA-directed DNA methylation, and in RNA-mediated antiviral defense. However, many crucial questions remain unanswered.
Ming-Bo, Wang, Michael, Metzlaff
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Emerging antiviral defense systems in fungi
Cell Host & MicrobeIn this issue of Cell Host & Microbe, Honda et al. identify an antiviral defense system in fungi. Mycoviruses trigger the expression of RNA-editing enzymes, which catalyze the editing of mRNAs encoding zinc finger transcription factors. This system differs from the RNA interference and is conserved in filamentous fungi.
Zeyu, Duan, Xiao, Liu
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Antiviral defense in plant stem cells
Trends in Plant ScienceUndifferentiated plant and animal stem cells are essential for cell, tissue, and organ differentiation, development, and growth. They possess unusual antiviral immunity which differs from that in specialized cells. By comparison to animal stem cells, we discuss how plant stem cells defend against viral invasion and beyond.
Jie Li +6 more
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Cytokine and Chemokine Networks: Pathways to Antiviral Defense
2007The complex interplays between cytokines and chemokines are emerging as key communication signals in the shaping of innate and adaptive immune responses against foreign pathogens, including viruses. In particular, the virus-induced expression of cytokine and chemokine profiles drives the recruitment and activation of immune effector cells to sites of ...
T P, Salazar-Mather, K L, Hokeness
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