Results 81 to 90 of about 951,212 (251)

Early host defense against virus infections

Cell Reports
Summary: Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease.
Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen   +6 more
doaj   +1 more source

THE MAIN CLINICAL SYNDROMES ASSOCIATED WITH ACTIVE CRONIC ATIPICAL EPSTEINE-BARR VIRUS INFECTION: CREATED ALGORITHM OF CLINICAL AND LABORATORY DIAGNOSTIC

RUDN Journal of Medicine, 2019
The annual steady increase of the herpesviral infections number in the human population is one of the most important interdisciplinary problems of modern medicine.
I. V. Nesterova, E. O. Khalturina
doaj   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Antiviral Res.

, 2014
Recombinant human interferon-omega (rhIFN-omega) exhibits a potent antiviral activity. Because of poor pharmacokinetics (PK) of rhIEN-omega, frequent dosing of rhIFN-omega is necessitated to achieve the sustained antiviral efficacy.
Fang, Ting, Chen, Wei, Yu, Weili, Hu, Tao, Wu, Ling, Zhang, Jinlong, Yu, Changming, Qiu, Rui, Fu, Ling, Yu, Ting   +9 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.

PLoS Biology
RNA interference (RNAi) mediates antiviral defense in many eukaryotes. Caenorhabditis elegans mutants that disable RNAi are more sensitive to viral infection. Many mutants that enhance RNAi have also been identified; these mutations may reveal genes that
Ashwin Seetharaman, Himani Galagali, Elizabeth Linarte, Mona H X Liu, Jennifer D Cohen, Kashish Chetal, Ruslan Sadreyev, Alex J Tate, Taiowa A Montgomery, Gary Ruvkun   +9 more
doaj   +1 more source

The Importance of Physiologically Relevant Cell Lines for Studying Virus–Host Interactions

Viruses, 2016
Viruses interact intimately with the host cell at nearly every stage of replication, and the cell model that is chosen to study virus infection is critically important.
David Hare, Susan Collins, Breanne Cuddington, Karen Mossman   +3 more
doaj   +1 more source

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +2 more sources

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Defense Governance and Management: Improving the Defense Management Capabilities of Foreign Defense Institutions [PDF]

, 2017
Part 1: Defense Policy and Strategy Development for Foreign Defense Institutions. Part 2: Defense Governance and Management: Defense Policy and Strategy Seminar MaterialThis two part paper is intended to assist United States government ...
Tillman, Mark E., Hinkle, Wade P., Neill, Martin, Morgan, Gary D., Taliaferro, Aaron C.   +4 more
core   +1 more source