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Antiviral drug resistance [PDF]
BMJ, 1998 The development of effective antiviral drugs is an important biomedical scientific achievement of the late 20th century. Highly potent drugs are now available against herpes viruses, HIV, hepatitis B virus, and influenza virus. This list will extend to papillomaviruses, respiratory viruses, enteroviruses, and hepatitis C virus over the next 5-10 years.
Davita Pillay, M Zambon
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Pharmacology of Antiviral Drugs
VirusesAntiviral drug therapy has significantly evolved over the past four decades, partly driven by improved understanding of viral replication mechanisms but also advances in pharmacology and formulation technologies [...]
David E. Martin
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Antiviral Drugs in Influenza [PDF]
International Journal of Environmental Research and Public Health, 2022 Flu is a serious health, medical, and economic problem, but no therapy is yet available that has satisfactory results and reduces the occurrence of these problems. Nearly 20 years after the registration of the previous therapy, baloxavir marboxil, a drug with a new mechanism of action, recently appeared on the market.
Magdalena Świerczyńska +2 more
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Hyperbranched Polymers: Recent Advances in Photodynamic Therapy against Cancer
Pharmaceutics, 2023 Hyperbranched polymers are a class of three-dimensional dendritic polymers with highly branched architectures. Their unique structural features endow them with promising physical and chemical properties, such as abundant surface functional groups ...
Jie Chen, Yichuan Zhang
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Frontiers in Cellular Neuroscience, 2022 N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in the mammalian brain and is associated with neurological diseases like Alzheimer ...
Fangfang Zhang +5 more
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Antiviral drugs and antiviral drug resistance [PDF]
Current Opinion in Virology, 2011 Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Richard J. Whitley, Donald M. Coen
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Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. [PDF]
, 2007 BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo.
A Adachi +67 more
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A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
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iScience, 2022 Summary: L3MBTL2 is a crucial component of ncPRC1.6 and has been implicated in transcriptional repression and chromatin compaction. However, the repression mechanism of L3MBTL2 and its biological functions are largely undefined.
Hua Huang +8 more
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