Results 61 to 70 of about 4,215,496 (299)

Antiviral Drug Discovery

International Journal of Molecular Sciences
A vast and painful price has been paid in the battle against viruses in global health [...]
Zhenzhen Zhou, Xinyong Liu, Dongwei Kang
openaire   +2 more sources

A prospect on the use of antiviral drugs to control local outbreaks of COVID-19

BMC Medicine, 2020
Background Current outbreaks of COVID-19 are threatening the health care systems of several countries around the world. Control measures, based on isolation, contact tracing, and quarantine, can decrease and delay the burden of the ongoing epidemic. With
A. Torneri, Pieter J. K. Libin, J. Vanderlocht, A. Vandamme, J. Neyts, N. Hens   +5 more
semanticscholar   +1 more source

Effect of paternal exposure to glyphosate and microcystin-LR on zebrafish (Danio rerio) fathers and progeny: An integrated investigation based on behavioral, histopathological, biochemical, and transcriptomic analysis

Ecotoxicology and Environmental Safety
The coexistence of glyphosate (GLY) and microcystin-LR (MC-LR) in the environment has become a problem that cannot be ignored. However, the combined toxic effects of these compounds on aquatic organisms remain underexplored. The purpose of this study was
Wei Liu, Yanlei Yang, Jingyu Han, Yiyi Feng, Junguo Ma, Xiaoyu Li   +5 more
doaj   +1 more source

Constructive strategies for drug delivery systems in antivirus disease therapy by biosafety materials

Biosafety and Health, 2022
Due to the coronavirus disease 2019 (COVID-19) pandemic, the development of antiviral drugs has attracted increasing attention. Clinical antiviral drugs show weak solubility, low bioavailability, adverse side effects, or only limited targets.
Li Wang, Zhaoshuo Wang, Lingzhi Cao, Kun Ge   +3 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Valganciclovir—Ganciclovir Use and Systematic Therapeutic Drug Monitoring. An Invitation to Antiviral Stewardship [PDF]

, 2021
Alicia Galar, Maricela Valerio, Pilar Catalán, Xandra García‐González, Almudena Burillo, Ana Fernández‐Cruz, Eduardo Zatarain‐Nicolás, Iago Sousa‐Casasnovas, Fernando Anaya, María Luisa Rodríguez-Ferrero, Patricia Muñóz, Emilio Bouza   +11 more
openalex   +1 more source

Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity [PDF]

, 2012
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling.
Balzarini, Jan, Martins, José, Sinnaeve, Davy, Van Calenbergh, Serge, Van Poecke, Sara   +4 more
core   +1 more source

Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs

Pharmaceutical Sciences and Research, 2023
Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses.
Maria Elvina Tresia Butar-Butar, Nasrul Wathoni, Hestiary Ratih, Yoga Windhu Wardhana   +3 more
doaj   +1 more source

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

The Use of Antimicrobial and Antiviral Drugs in Alzheimer’s Disease

International Journal of Molecular Sciences, 2020
The aggregation and accumulation of amyloid-β plaques and tau proteins in the brain have been central characteristics in the pathophysiology of Alzheimer’s disease (AD), making them the focus of most of the research exploring potential therapeutics for ...
Umar Iqbal, Emma Zeng, G. Pasinetti
semanticscholar   +1 more source