Results 131 to 140 of about 88,094 (292)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks

Clinical &Experimental Allergy, EarlyView.
In the phase 3 KONFIDENT trial of oral sebetralstat for on‐demand treatment of hereditary angioedema attacks, many attacks induced moderate‐to‐extreme anxiety. Sebetralstat reduced anxiety versus placebo; time to reductions agreed with trial endpoints, such as time to beginning of symptom relief.
Timothy Craig, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Paula J. Busse, Teresa Caballero, Danny M. Cohn, Mar Guilarte, Henriette Farkas, Douglas H. Jones, Sorena Kiani‐Alikhan, Michael E. Manning, Marcus Maurer, Marc A. Riedl, Sinisa Savic, H. James Wedner, Patrick F. K. Yong, Andrea Zanichelli, Sally van Kooten, Matthew Iverson, Erik Hansen, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, William R. Lumry   +24 more
wiley   +1 more source

Avaliação da atividade ansiolítica e antidepressiva do extrato fluido e fração aquosa de folhas de Passiflora alata Curtis em camundongos = Evaluation of anxiolytic and antidepressant activities in mice with fluid extracts and aqueous fraction obtained from the leaves of Passiflora alata

Acta Scientiarum. Health Sciences, 2006
O extrato fluido (EF), preparado segundo a Farmacopéia Brasileira, e sua fração aquosa (FA) obtidos de folhas de Passiflora alata foram administrados por via oral em camundongos.
Cássia Valério Romanini, Michelli Wesz Machado, Maique Weber Biavatti, Rúbia Maria Weffort de Oliveira   +3 more
doaj  

SEMASEARCH Study Design: Real‐World Evaluation of Semaglutide 2.4 mg in Adults With Severe Obesity Underrepresented in Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Although semaglutide 2.4 mg has demonstrated significant weight loss efficacy in clinical trials, real‐world data, particularly with regard to clinically complex and underrepresented populations, remain limited. Objectives The study aims to assess the real‐world effectiveness and patient‐reported outcomes associated with the use of ...
Pierre Bel Lassen, David Jacobi, Marie‐Claude Brindisi, Jean‐Baptiste Bonnet, Fabien Subtil, Sylvie Bin, Fanny Abad, Christine Poitou, Bérénice Segrestin, Séverine Ledoux, Bénédicte Gaborit, Judith Aron‐Wisnewsky, Claire Carette, Mohamed Zerguine, Blandine Gatta‐Cherifi, Didier Quilliot, Emilie Montastier, Antoine Avignon, Héléna Mosbah, Sébastien Czernichow, Emmanuel Disse   +20 more
wiley   +1 more source

Use of Glucagon‐Like Peptide‐1 Receptor Agonists and Risk of Parkinson's Disease: Scandinavian Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate the association between use of GLP‐1 receptor agonists and incident Parkinson's disease. Material and Methods Cohort study using data from nationwide registers in Denmark, Norway and Sweden and an active‐comparator, new‐user design.
Arvid Engström, Henrik Svanström, Anders Hviid, Björn Eliasson, Soffia Gudbjörnsdottir, Viktor Wintzell, Kristian Hveem, Christian Jonasson, Mads Melbye, Peter Ueda, Björn Pasternak   +10 more
wiley   +1 more source

Conventional cigarettes, novel heated tobacco products, and self‐reported frequent headache association in Japanese individuals: Insights from the JASTIS study, a Japanese cross‐sectional analysis

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Headache is a common health problem, and tobacco products, such as conventional cigarettes and heated tobacco products (HTPs), may be associated with it. Using data from over 23,000 adults in the Japan Society and New Tobacco Internet Survey, we examined the relationships between cigarette and HTP use and self‐reported frequent ...
Masahito Katsuki, Kieran Moran, Muneto Tatsumoto, Keisuke Suzuki, Tomokazu Shimazu, Yasuhiko Matsumori, Yutaro Fuse, Miguel Á. Huerta, Daijiro Sugiyama, Jackson T. S. Cheung, Siobhán O'Connor, Tomás Ward, Takahiro Tabuchi   +12 more
wiley   +1 more source

Chronotype in migraine and tension‐type headache: A population study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives This study was designed to examine the distribution of chronotypes among individuals with migraine and tension‐type headache and to evaluate the association between chronotype and clinical headache characteristics in a population‐based sample. Background Although previous research has demonstrated associations between chronotype and
Da Eun Jung, Soomi Cho, Woo‐Seok Ha, Hye Jung Shin, Min Kyung Chu   +4 more
wiley   +1 more source