Results 51 to 60 of about 71,529 (343)

Experimental pharmacological research regarding some new quinazolin-4-ones derivatives

Journal of Mind and Medical Sciences, 2019
A series of new compounds with quinazolin-4-one structure, synthesized by the Pharmaceutical Chemistry Department of the Faculty of Pharmacy of the University of Medicine and Pharmacy “Carol Davila” Bucharest, was studied.
Cornel Chiriță, Emil Ștefănescu, Cristina Elena Zbârcea, Simona Negreș, Mihaela Bratu, Diana Camelia Nuță, Carmen Limban, Ileana Cornelia Chiriță, Cristina Daniela Marineci   +8 more
doaj   +1 more source

Unveiling Pharmacological Responses and Potential Targets Insights of Identified Bioactive Constituents of Cuscuta reflexa Roxb. Leaves through In Vivo and In Silico Approaches

Pharmaceuticals, 2020
Cuscuta reflexa Roxb. is traditionally used by the indigenous communities of Bangladesh to treat different diseases, such as pain, edema, tumor, jaundice, and skin infections.
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, Md. Riad Chowdhury, Md. Shariful Islam, Md. Amzad Hossain, Abu Montakim Tareq, Md. Imam Hossain Bhuiyan, Md Nasim Uddin, Afroza Tahamina, Md Obyedul Kalam Azad, Young Seok Lim, Dong Ha Cho   +12 more
doaj   +1 more source

The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety: An In Vivo Subacute Study

Molecules, 2021
Depression and anxiety are major mental health problems in all parts of the world. These illnesses are associated with a number of risk factors, including oxidative stress.
Imane Es-safi, Hamza Mechchate, Amal Amaghnouje, Omkulthom Mohamed Al Kamaly, Fatima Zahra Jawhari, Hamada Imtara, Andriy Grafov, Dalila Bousta   +7 more
doaj   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Establishing zebrafish as a model to study the anxiolytic effects of scopolamine

Scientific Reports, 2017
Scopolamine (hyoscine) is a muscarinic acetylcholine receptor antagonist that has traditionally been used to treat motion sickness in humans. However, studies investigating depressed and bipolar populations have found that scopolamine is also effective ...
T. Hamilton, Adam Morrill, K. Lucas, Joshua Gallup, Megan Harris, Meghan Healey, Taylor Pitman, Melike Schalomon, S. Digweed, M. Tresguerres   +9 more
semanticscholar   +1 more source

Visible Light‐Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs

Chemistry – An Asian Journal, EarlyView.
A new visible light‐induced method is reported for the C3‐alkylation of imidazo[1,2‐a]pyrimidines and ‐pyridines with aryldiazoacetates. This protocol can be performed in open air and serves as a convenient entry to several known and new molecules. A formal synthesis of zolpidem is achieved by changing the alkylating agent to an appropriate hypervalent
Ronei M. S. Souza, Tales A. C. Goulart, Roberto do C. Pinheiro, Felipe F. do C. Sonaglio, Deborah de A. Simoni, Rodrigo A. Cormanich, Igor D. Jurberg   +6 more
wiley   +1 more source

Procognitive, Anxiolytic, and Antidepressant-like Properties of Hyperoside and Protocatechuic Acid Corresponding with the Increase in Serum Serotonin Level after Prolonged Treatment in Mice

Pharmaceuticals, 2023
Two polyphenols–hyperoside (HYP) and protocatechuic acid (PCA) were reported to exert antidepressant activity in rodents after acute treatment. Our previous study also showed that this activity might have been influenced by the monoaminergic system and ...
Jolanta Orzelska-Górka, Katarzyna Dos Santos Szewczyk, Monika Gawrońska-Grzywacz, Mariola Herbet, Anna Lesniak, Anna Bielenica, Magdalena Bujalska-Zadrożny, Grażyna Biała   +7 more
doaj   +1 more source

The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats

Scientific Reports, 2018
The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). The anxiolytic-like activities were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced by blocking the decreased time and entries in the open arms in ...
Jia-ning Xu, Li-fang Chen, Jun Su, Zhi-li Liu, Jie Chen, Qing-fen Lin, Weidong Mao, D. Shen   +7 more
semanticscholar   +1 more source

Implementing physician‐led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen, Signe Wegmann Düring, Gesche Jürgens   +2 more
wiley   +1 more source

Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves of Aloysia polystachya (Griseb.) Moldenke: A Study on Zebrafish (Danio rerio)

Pharmaceuticals, 2019
Medicinal plants such as Aloysia polystachya are often used in the treatment of psychiatric diseases, including anxiety- and depression-related humor disturbances. In folk medicine, A.
Nayara Costa de Melo, Brenda Lorena Sánchez-Ortiz, Tafnis Ingret dos Santos Sampaio, Arlindo César Matias Pereira, Fernando Luiz Pinheiro da Silva Neto, Heitor Ribeiro da Silva, Rodrigo Alves Soares Cruz, Hady Keita, Ana Maria Soares Pereira, José Carlos Tavares Carvalho   +9 more
doaj   +1 more source