Results 61 to 70 of about 45,720 (293)

The efficacy of trazodone in reducing stress related behaviours in hospitalised dogs or dogs confined postsurgery

Veterinary Evidence, 2023
PICO question In hospitalised dogs or dogs confined postsurgery, does administration of trazodone reduce stress related behaviours compared to no treatment with trazodone?   Clinical bottom line Category of research Treatment. Number and type
Lara Dillon
doaj   +1 more source

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

The impact of single‐dose trazodone administration on plasma endogenous adrenocorticotropic hormone and serum cortisol concentrations in healthy dogs

Journal of Veterinary Internal Medicine
Background Conditions affecting the hypothalamic‐pituitary‐adrenal (HPA) axis are common in dogs. Testing the function of the HPA axis includes measurement of endogenous adrenocorticotropic hormone (eACTH) and performance of an adrenocorticotropic ...
Morgan Brown, Tekla Lee‐Fowler, Ellen N. Behrend, Megan Grobman   +3 more
doaj   +1 more source

Characteristics of the basal psychoautonomous indicators in patients after coronary artery stent placement at various stages of rehabilitation

Alʹmanah Kliničeskoj Mediciny, 2023
Background: Clinically significant psychoautonomous syndrome, along with other modifiable factors (obesity, dyslipidemia, low physical activity, smoking, arterial hypertension, etc.) increases the risk of development and progression of coronary artery ...
Ruslan A. Mirzoev, Svetlana V. Malchikova, Mikhail A. Sherman   +2 more
doaj   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Development and acceptability of a decision aid for anxiety disorder considering discontinuation of benzodiazepine anxiolytic

Frontiers in Psychiatry, 2023
AimWe aimed to develop a decision aid (DA) for individuals with anxiety disorders who consider tapering benzodiazepine (BZD) anxiolytics, and if tapering, tapering BZD anxiolytics with or without cognitive behavioral therapy (CBT) for anxiety.
Yumi Aoki, Yumi Aoki, Yoshikazu Takaesu, Yoshikazu Takaesu, Ken Inada, Hiroki Yamada, Tomohiko Murao, Toshiaki Kikuchi, Masahiro Takeshima, Masayuki Tani, Kazuo Mishima, Tempei Otsubo   +11 more
doaj   +1 more source

Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT)

British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 390-400, January 2023., 2023
Aims In the last French study in 2007, the incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective was to assess the current ADR‐HA incidence in France and to describe both its characteristics and preventability.
Marie‐Laure Laroche, Sophie Gautier, Elisabeth Polard, Marie‐Blanche Rabier, Laurent Chouchana, Bénédicte Lebrun‐Vignes, Jean‐Luc Faillie, Nadine Petitpain, Laurence Lagarce, Annie‐Pierre Jonville‐Bera, for the IATROSTAT study group   +10 more
wiley   +1 more source

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

ChemSusChem, Accepted Article.
This review critically examines the dual nature of chlorine as both an indispensable base chemical and a potential risk. Chlorine and its by‐product hydrogen chloride play essential roles in the production of pharmaceuticals, plastics, agrochemicals, and disinfectants.
Johannes Schwan, Merlin Kleoff, Gesa H. Dreyhsig, Patrick Voßnacker, Traute Fiedler, Marian Rosental, Sebastian Riedel   +6 more
wiley   +1 more source

Use of benzodiazepines and benzodiazepine‐related drugs in the Nordic countries between 2000 and 2020

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 60-70, January 2023., 2023
Abstract Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ‐sedatives, BZ‐hypnotics, and benzodiazepine‐related drugs (BZRD) in adults (≥20 years) were obtained from ...
Mikkel Højlund, Larus S. Gudmundsson, Jacob H. Andersen, Leena K. Saastamoinen, Helga Zoega, Svetlana O. Skurtveit, Jonas W. Wastesson, Jesper Hallas, Anton Pottegård   +8 more
wiley   +1 more source

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

Drug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman, Marie H. Deventer, Rachael Andrews, Robert Reid, Victoria Marland, Darren Edwards, Christopher R. Pudney, Niamh Nic Daéid, Christophe P. Stove, Caitlyn Norman   +9 more
wiley   +1 more source