Results 71 to 80 of about 73,505 (352)

Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish

Chemistry &Biodiversity, EarlyView.
ABSTRACT Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxicity and maintained normal locomotor activity.
Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, Maria Auxiliadora Solange Silva Gondim Pereira, Emanuela de Lima Rebouças, Francisco das Chagas L. Pinto, Matheus Nunes da Rocha, Maria Kueirislene Amâncio Ferreira, Janaina Serra Azul Monteiro Evangelista, Izabel Florindo Guedes, Marcia Machado Marinho, Emmanuel Silva Marinho, Andreia Ferreira de Castro Gomes, Otília Loiola Pessoa, Jane Eire Silva Alencar de Menezes, Hélcio Silva dos Santos   +15 more
wiley   +1 more source

Neuropharmacological evaluation of methanolic extract of Costus speciosus Linn. rhizome in Swiss albino mice

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To evaluate the neuropharmacological properties of Costus speciosus (C. speciosus) rhizome using different experimental mouse models. Methods: The anxiolytic effect was investigated by hole-board test, elevated plus maze and light/dark test ...
Umay Chen, Md. Saddam Hussain, Tanoy Mazumder, S M Naim Uddin, Sujan Banik   +4 more
doaj   +1 more source

Conocarpus lancifolius (Combretaceae): Pharmacological Effects, LC-ESI-MS/MS Profiling and In Silico Attributes

Metabolites, 2023
In folklore medicine, Conocarpus lancifolius is used to treat various illnesses. The main objective of this study was a comprehensive investigation of Conocarpus lancifolius leaf aqueous extract (CLAE) for its antioxidant, cardioprotective, anxiolytic ...
Muhammad Khurm, Yuting Guo, Qingqing Wu, Xinxin Zhang, Muhammad Umer Ghori, Muhammad Fawad Rasool, Imran Imran, Fatima Saqib, Muqeet Wahid, Zengjun Guo   +9 more
doaj   +1 more source

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

The impact of single‐dose trazodone administration on plasma endogenous adrenocorticotropic hormone and serum cortisol concentrations in healthy dogs

Journal of Veterinary Internal Medicine
Background Conditions affecting the hypothalamic‐pituitary‐adrenal (HPA) axis are common in dogs. Testing the function of the HPA axis includes measurement of endogenous adrenocorticotropic hormone (eACTH) and performance of an adrenocorticotropic ...
Morgan Brown, Tekla Lee‐Fowler, Ellen N. Behrend, Megan Grobman   +3 more
doaj   +1 more source

Clinical effects of central antagonist of cholecystokinin-1 receptors GB-115 in patients with Generalized Anxiety Disorder

European Psychiatry, 2022
Introduction The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily.
O. Dorofeeva, T. Syunyakov, M. Metlina, N. Ivashkina   +3 more
doaj   +1 more source

Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus

Scientific Reports, 2017
Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined.
Xiao-Juan Li, Qing-Yu Ma, You-ming Jiang, Xiao-hui Bai, Zhiyi Yan, Qun Liu, Qiuxia Pan, Yue-yun Liu, Jia-xu Chen   +8 more
semanticscholar   +1 more source

GenoStaR: An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety.
Alex J. Coulter, Megana Thamilselvan, James L. Kennedy, Clement C. Zai, Arun K. Tiwari   +4 more
wiley   +1 more source

Comparing Outcomes for Telehealth Versus In‐Person Family‐Based Treatment: A Retrospective Chart Review

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Telehealth services have become part of many eating disorder (ED) treatment settings; yet, few studies have examined the effectiveness of family‐based treatment (FBT) delivered via telehealth. This study compared in‐person and telehealth FBT in rates of weight restoration, treatment completion, and metrics of treatment progress, and ...
Catherine R. Drury, Simar Singh, Michael Manzano, Sasha Gorrell, Erin E. Reilly, Michelle Odette, Erin C. Accurso, Leigh Brosof, Lindsey Bruett, Sarah Forsberg, Verena Haas, Lisa Hail, Kathryn M. Huryk, Jessica Keyser, Rachel Kramer, Naomi Lynch, Stuart B. Murray, Rachel M. Radin, Justine Underhill, Kianna Zucker, Daniel Le Grange   +20 more
wiley   +1 more source

Seminars in epileptology: Presurgical epilepsy evaluation

Epileptic Disorders, EarlyView.
Abstract All patients with drug‐resistant seizures benefit from a comprehensive evaluation to confirm their seizure diagnosis and explore surgical treatment options. This seminar in epileptology discusses advancements in the field and provides specific didactic material to create an active working knowledge for the care of patients with focal drug ...
Stephan Schuele, Robyn M. Busch, Birgit Frauscher, Vadym Gnatkovsky, Hajo Hamer, Lara Jehi, Andres Kanner, Georgia Ramantani, Theodor Rüber, Andreas Schulze‐Bonhage, Rainer Surges, Lara Wadi   +11 more
wiley   +1 more source