Results 81 to 90 of about 71,529 (343)

Animal models for screening anxiolytic-like drugs: a perspective

Dialogues in Clinical Neuroscience, 2015
Contemporary biological psychiatry uses experimental animal models to increase our understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly targets specific pathways and molecular determinants within a single phenotypic ...
M. Bourin
semanticscholar   +1 more source

Predictors of Anorexia Nervosa and Obsessive‐Compulsive Disorder Comorbidity and Order of Diagnosis in a Danish National Cohort

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) and obsessive‐compulsive disorder (OCD) are highly comorbid; however, limited research has examined etiological pathways specific to individuals with AN developing OCD or individuals with OCD developing AN. This exploratory study aimed to identify factors influencing AN‐OCD comorbidity with a focus on the order ...
Lisa Yujia Zhu, Janne Tidselbak Larsen, Judith Becker Nissen, James J. Crowley, Manuel Mattheisen, Cynthia M. Bulik, Liselotte Vogdrup Petersen, Zeynep Yilmaz   +7 more
wiley   +1 more source

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.

Journal of Medicinal Chemistry, 2016
1,4-Benzodiazepines are used in the treatment of anxiety disorders but have limited long-term use due to adverse effects. HZ-166 (2) has been shown to have anxiolytic-like effects with reduced sedative/ataxic liabilities.
M. Poe, K. R. Methuku, Guanguan Li, Ashwini R Verma, Kelly A. Teske, D. Stafford, L. Arnold, J. Cramer, T. M. Jones, R. Černe, Michael J. Krambis, J. Witkin, E. Jambrina, S. Rehman, M. Ernst, J. Cook, J. Schkeryantz   +16 more
semanticscholar   +1 more source

Effects of Lactobacillus fermentum GKF3 on Reducing Smoking and Brain Neurotransmitter Levels: Findings From Animal and Human Studies

Food Frontiers, EarlyView.
1.Developing food‐grade probiotic strains with smoking reduction benefits presents a safer and more holistic health strategy. 2.An animal study demonstrated that L. fermentum GKF3 gavage elevated brain dopamine and serotonin levels. 3.A randomized controlled trial showed that L.
You‐Shan Tsai, Shan Lin, Chin‐Chu Chen, Chun‐Hung Chiu, Mei‐Chin Mong, Shu‐Ling Hu, Chi‐Hao Wu   +6 more
wiley   +1 more source

The impact of single‐dose trazodone administration on plasma endogenous adrenocorticotropic hormone and serum cortisol concentrations in healthy dogs

Journal of Veterinary Internal Medicine
Background Conditions affecting the hypothalamic‐pituitary‐adrenal (HPA) axis are common in dogs. Testing the function of the HPA axis includes measurement of endogenous adrenocorticotropic hormone (eACTH) and performance of an adrenocorticotropic ...
Morgan Brown, Tekla Lee‐Fowler, Ellen N. Behrend, Megan Grobman   +3 more
doaj   +1 more source

Functional Characteristics of Bioactive Millet Peptides: A Comprehensive Review

Future Postharvest and Food, EarlyView.
The graphical abstract of this paper highlights the functional characteristics of bioactive peptides derived from millets. It is a promising ingredient and can be used in various applications in food, pharmaceuticals, and healthcare industries and possess biological functions.
Kouser Jan, Aamir Hussain Dar, Kshirod Kumar Dash, Shivangi Srivastava, Vinay Kumar Pandey, Parmjit S. Panesar, Wani Suhana Ayoub, Entesar Hanan, Iqra Bashir, Anurag Singh, Shafat Ahmad Khan   +10 more
wiley   +1 more source

Anxiolytic and sedative-like effects of flavonoids from Tilia Americana var. Mexicana: GABAergic and serotonergic participation

, 2016
Introduction. The inflorescences of Tilia americana var. mexicana are used as an infusion in Mexican traditional medicine due to their tranquilizing effects; however, pharmacological and phytochemical studies of the leaves are lacking. Objective. In this
E. Aguirre-Hernández, M. González-Trujano, T. Terrazas, J. H. Santoyo, P. Guevara-Fefer   +4 more
semanticscholar   +1 more source

Therapeutic Use of Cannabis Derivatives and Their Analogs for Autism Spectrum Disorder: A Systematic Review

The Journal of Clinical Pharmacology, EarlyView.
Abstract Autism spectrum disorders are characterized by some difficulties with social interactions and communication, atypical patterns of behavior, and unusual reactions to emotions. Studies have found promising results regarding the effects of cannabis on autism.
Rachel Riera, Isabela Porto de Toledo, Cecília Menezes Farinasso, Rafael Leite Pacheco, Roberta Borges Silva, Verônica Colpani, Ana Luiza Cabrera Martimbianco, Camila Monteiro Cruz, Patrícia do Carmo Silva Parreira, Carolina de Oliveira Cruz Latorraca   +9 more
wiley   +1 more source

Multimorbidity and use of hypnotic and anxiolytic drugs: cross-sectional and follow-up study in primary healthcare in Iceland

BMC Family Practice, 2016
BackgroundThe prevalence of multimorbidity is increasing worldwide, presumably leading to an increased use of medicines. During the last decades the use of hypnotic and anxiolytic benzodiazepine derivatives and related drugs has increased dramatically ...
K. Linnet, L. Gudmundsson, Frida G. Birgisdottir, E. Sigurdsson, M. Jóhannsson, M. O. Tomasdottir, J. Sigurdsson   +6 more
semanticscholar   +1 more source

PEG‐Free Nanoemulsions With Alkyl Polyglucoside and Baccharis dracunculifolia Essential Oil: Physicochemical Behavior, pH Dependence and Skin Repair Properties

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT Alkyl polyglucosides (APG) are biodegradable, non‐ionic surfactants from renewable sources with low ecotoxicity. This study developed a novel PEG‐free nanoemulsion (NE) using APG to encapsulate Baccharis dracunculifolia essential oil (BDO) for skin repair.
Carolina Sousa Ponciano, Fernanda Brito Leite, Carine Cassimiro Cedrola, Julliana da Fonseca Alves, Ana Cláudia Chagas de Paula, Luiz Fernando Cappa de Oliveira, Thais Nogueira Barradas, Fernanda Maria Pinto Vilela   +7 more
wiley   +1 more source