Results 151 to 160 of about 574,230 (187)

Progression of aortic valve sclerosis to aortic stenosis

The American Journal of Cardiology, 2003
level or low-density lipoprotein cholesterol and high-density lipoprotein cholesterol concentrations. Itwould be interesting to know the effects of thesefactors on severe calcific AS.In summary, this large case-control study showsthat the development of severe AS caused by thecalcific degenerative process is not simply a conse-quence of aging.
Pompilio, Faggiano, Francesco, Antonini-Canterin, Andrea, Erlicher, Cristina, Romeo, Eugenio, Cervesato, Daniela, Pavan, Rita, Piazza, Guoqian, Huang, Gian Luigi, Nicolosi   +8 more
openaire   +2 more sources

Aortic Valve Sclerosis and Clinical Outcomes: Moving Toward a Definition

American Journal of Medicine, 2011
The presence of aortic valve sclerosis has been suggested as a marker of increased cardiovascular risk, including increased mortality. However, it remains unclear whether aortic valve sclerosis is independently associated with risk or merely a marker of coexistent cardiovascular risk factors. Aortic valve sclerosis is usually diagnosed on transthoracic
Clarence Shub, S Michael Gharacholou
exaly   +3 more sources

Metabolomics of aortic valve stenosis: Are aortic valve stenosis and sclerosis different diseases?

Atherosclerosis
Calcific aortic valve disease (CAVD) shares the same risk factors as atherosclerotic vascular diseases (ASVD). However, in contrast to ASVD, treating the risk factors has not been shown to be effective in preventing CAVD and its progression to aortic stenosis (AS). Thus, the ultimate pathophysiology of CAVD remains unknown. This study aimed to evaluate
Olli Kärkkäinen, Jaana Rysa
exaly   +4 more sources

Statin treatment of hypercholesterolemic-induced aortic valve sclerosis

Cardiovascular Pathology, 2011
Aortic valve sclerosis (AVS) is a common inflammatory heart valve disease prevalent in the population over the age of 65 years. Several published clinical and animal studies have examined the ability of statin treatment to modify disease progression. Clinical trials yielded conflicting results, and animal studies examined the effects of statins prior ...
Kem Rogers, Derek R Boughner
exaly   +3 more sources

Aortic Pulse Wave Velocity in Subjects with Aortic Valve Sclerosis

Echocardiography, 2008
Background: Aortic stiffness is an independent risk factor for cardiovascular events and mortality. The measurement of pulse‐wave velocity (PWV) is the most simple, noninvasive, and robust method to determine aortic stiffness. Whether aortic stiffness contributes to aortic valve sclerosis (AVS) remains unknown.
Sükrü, Celik, Ismet, Durmuş, Levent, Korkmaz, Omer, Gedikli, Sahin, Kaplan, Cihan, Orem, Merih, Baykan   +6 more
openaire   +2 more sources

Echocardiographic progression of calcific aortic valve disease in patients with preexisting aortic valve sclerosis

2022
Abstract Objective We aimed to evaluate echocardiographic parameters to predict CAVD progression. Background Calcific aortic valve disease (CAVD) ranges from aortic valve sclerosis (ASc) with no functional impairment of the aortic ...
Jasmin Shamekhi, Carina Uehre, Baravan Al-Kassou, Marcel Weber, Alexander Sedaghat, Atsushi Sugiura, Nihal Wilde, Matti Adam, Verena Veulemans, Malte Kelm, Stephan Baldus, Georg Nickenig, Sebastian Zimmer   +12 more
openaire   +1 more source

Identification of tissue factor in experimental aortic valve sclerosis

Cardiovascular Pathology, 2009
Aortic valve sclerosis (AVS) shares epidemiological and histological similarities with atherosclerosis. Tissue factor (TF), the main initiator of blood coagulation, is present in atherosclerotic plaques and contributes to their thrombogenicity. We aimed to analyze valvular TF expression in addition to other components of atherosclerosis in two models ...
Sylvestre, Marechaux, Delphine, Corseaux, Andre, Vincentelli, Marjorie, Richardson, Alexandre, Ung, Sophie, Susen, Christophe, Zawadzki, Jean-Paul, Beregi, Michael D, Ezekowitz, Brigitte, Jude, Thierry, Le Tourneau   +10 more
openaire   +2 more sources

Progression of calcific aortic valve sclerosis in WHHLMI rabbits

Atherosclerosis, 2018
Aortic valve stenosis (AS) is the most common valvular heart disease and can be life-threatening. The pathogenesis of aortic valve calcification remains largely unknown, primarily due to the lack of an adequate animal model. The high-cholesterol diet-induced AS model in rabbits is one of the established models, but it has the significant limitation of ...
Tetsuya Hara, Norie Tsukada, Mitsumasa Okano, Tatsuro Ishida, Ken-ichi Hirata, Masashi Shiomi   +5 more
openaire   +2 more sources

Association of Aortic-Valve Sclerosis with Cardiovascular Mortality and Morbidity in the Elderly

New England Journal of Medicine, 1999
Although aortic-valve stenosis is clearly associated with adverse cardiovascular outcomes, it is unclear whether valve sclerosis increases the risk of cardiovascular events.We assessed echocardiograms obtained at base line from 5621 men and women 65 years of age or older who were enrolled in a population-based prospective study.
Dalane W Kitzman
exaly   +3 more sources

Evaluation of a porcine model of early aortic valve sclerosis

Cardiovascular Pathology, 2014
Calcific aortic valve disease (CAVD) is associated with significant cardiovascular morbidity. While late-stage CAVD is well-described, early pathobiological processes are poorly understood due to the lack of animal models that faithfully replicate early human disease.
Krista L. Sider, Cuilan Zhu, Andrea V. Kwong, Zahra Mirzaei, Cornelius F.M. de Langé, Craig A. Simmons   +5 more
openaire   +2 more sources