Results 1 to 10 of about 5,149,759 (252)

NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease [PDF]

Frontiers in Cardiovascular Medicine, 2021
NOTCH intercellular signaling mediates the communications between adjacent cells involved in multiple biological processes essential for tissue morphogenesis and homeostasis. The NOTCH1 mutations are the first identified human genetic variants that cause congenital bicuspid aortic valve (BAV) and calcific aortic valve disease (CAVD).
Bin Zhou, Yidong Wang, Pengfei Lu
exaly   +6 more sources

Macrophages as key modulators of calcific aortic valve disease [PDF]

Frontiers in Cardiovascular Medicine
Calcific aortic valve disease (CAVD), defined by thickening, fibrosis, and mineralization of the aortic valve (AV) leaflets, is the most common valvular heart disease worldwide. This progressive remodeling gradually impairs valve opening, obstructing blood flow.
Alexandre Candellier, Bennis Y, Lucie Henaut   +2 more
exaly   +5 more sources

The Haemodynamic and Pathophysiological Mechanisms of Calcific Aortic Valve Disease

Biomedicines, 2022
The aortic valve (AoV) is the outflow valve for the left heart [...]
Lydia Hanna, Xiao Xu, Chloe Armour
exaly   +6 more sources

Calcific Aortic Valve Disease [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis.
Yutzey, KE, Demer, LL, Body, SC, Huggins, GS, Towler, DA, Giachelli, CM, Hofmann-Bowman, MA, Mortlock, DP, Rogers, MB, Sadeghi, MM, Aikawa, E   +10 more
core   +8 more sources

The role of microRNAs in calcific aortic valve disease. [PDF]

Front Cardiovasc Med
Calcific aortic valve disease (CAVD) is a prevalent and progressive valvular disorder characterized by fibrocalcific remodeling and eventual valve stenosis. Despite its clinical burden, current treatment is limited to valve replacement at end-stage disease, with no approved medical therapy to slow or halt its progression.
Peng YZ, He Y, Yang YJ, Tang L.
europepmc   +4 more sources

Decoding the lactylation-immune link in calcific aortic valve disease: a comprehensive bioinformatics approach [PDF]

Human Genomics
Background Calcific aortic valve disease is a progressive disorder characterized by pathological leaflet thickening and calcification. Early disease features include immune cell infiltration and metabolic dysregulation, which persist throughout disease ...
Gaofeng Li, Jinchi Zhang, Xiang Qiu, Fuqiang Tong, Xiuqi Hu, Wenyi Wan, Zongqi Han, Weihua Qiao, Nianguo Dong   +8 more
doaj   +2 more sources

Sex-Specific Features of Calcific Aortic Valve Disease

International Journal of Molecular Sciences, 2020
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in developed countries predominantly affecting the elderly population therefore posing a large economic burden. It is a gradually progressive condition ranging from mild valve calcification and thickening, without the hemodynamic obstruction, to severe calcification ...
Veronika Myasoedova, Alexander Orekhov, Paolo Poggio   +2 more
exaly   +3 more sources

Deciphering the Enigma of Calcific Aortic Valve Disease: The Pivotal Role of Animal Models in Unraveling Pathogenesis and Advancing Therapeutic Strategies [PDF]

Biomedicines
Calcific aortic valve disease (CAVD) is a prevalent cardiovascular condition and is the most common heart valve disease globally. Hyperlipidemia and aging are key risk factors; consequently, with the aging global population, CAVD incidence continues to ...
Pengning Fan, Yuqi Liu, Xingyu Qian, Fuqiang Tong, Yidan Zheng, Zhengfeng Fan, Ming Chen, Zhe Chen, Haoyang Zhai, Teng Zeng, Nianguo Dong, Fei Li, Xucong Shi, Li Xu   +13 more
doaj   +2 more sources

Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Calcific aortic valve disease (CAVD), and ensuing severe aortic stenosis (AS), is the foremost valvular disorder of aging, yet preventive therapies are lacking.
Anna E. Bortnick, Thomas R. Austin, Emily Hamerton, Valborg Gudmundsdottir, Valur Emilsson, Lori L. Jennings, Vilmundur Gudnason, David S. Owens, Daniele Massera, Line Dufresne, Ta‐Yu Yang, James C. Engert, George Thanassoulis, Russell P. Tracy, Robert E. Gerszten, Bruce M. Psaty, Jorge R. Kizer   +16 more
doaj   +2 more sources

Calcific Aortic Valve Disease [PDF]

Circulation Research, 2017
Despite the high prevalence and severe consequences of calcific aortic valve disease (CAVD), its pathogenesis remains relatively poorly understood. For many years, CAVD was considered a degenerative disease, where calcification was a consequence of normal aging.
Ana M, Porras, Chloé M, McCoy, Kristyn S, Masters   +2 more
openaire   +5 more sources