Results 11 to 20 of about 5,149,759 (252)

Contribution of Oxidative Stress (OS) in Calcific Aortic Valve Disease (CAVD): From Pathophysiology to Therapeutic Targets

Cells, 2022
Calcific aortic valve disease (CAVD) is a major cause of cardiovascular mortality and morbidity, with increased prevalence and incidence. The underlying mechanisms behind CAVD are complex, and are mainly illustrated by inflammation, mechanical stress ...
Daniela Maria Tanase, Emilia Valasciuc, Evelina Maria Gosav, Mariana Floria, Claudia Florida Costea, Nicoleta Dima, Ionut Tudorancea, Minela Aida Maranduca, Ionela Lacramioara Serban   +8 more
doaj   +2 more sources

Gene expression profiling of human calcific aortic valve disease [PDF]

Genomics Data, 2016
Calcific aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening (i.e. aortic sclerosis) to severe calcification of valves (i.e. aortic stenosis).
Jaana Rysä
doaj   +2 more sources

Inhibitory role of Notch1 in calcific aortic valve disease. [PDF]

PLoS ONE, 2011
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown.
Asha Acharya, Chetan P Hans, Sara N Koenig, Haley A Nichols, Cristi L Galindo, Harold R Garner, Walter H Merrill, Robert B Hinton, Vidu Garg   +8 more
doaj   +2 more sources

Monitoring Calcific Aortic Valve Disease: The Role of Biomarkers

Current Medicinal Chemistry, 2012
Calcific aortic valve disease is a common disease in the elderly associated with significant morbidity and mortality. It was once described as a passive degenerative process during which serum calcium attaches to the valve surface and binds to the leaflet.
Latsios, G., Tousoulis, D., Androulakis, E., Papageorgiou, N., Synetos, A., Tsioufis, C., Toutouzas, K., Stefanadis, C.   +7 more
core   +5 more sources

KLF5 Downregulation Links Impaired BNIP3-Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease. [PDF]

Adv Sci (Weinh)
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Bian JH, Gu JX, Yue Z, Yuan CZ, Ji HB, Li A, Zhong Y, Xu XF, He YQ, Jiang YF, Chen HS, Chen X, Chao ML, Shao YF.   +13 more
europepmc   +2 more sources

Calcific Aortic Valve Disease [PDF]

, 2013
Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment ...
Laura Iop, Gino Geros, IOP, LAURA, GEROSA, GINO   +3 more
core   +4 more sources

Potential biomarkers and immune cell infiltration involved in aortic valve calcification identified through integrated bioinformatics analysis

Frontiers in Physiology, 2022
Background: Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the aging population, resulting in a significant health and economic burden worldwide, but its underlying diagnostic biomarkers and pathophysiological ...
Xiaoshuo Lv, Xiaoshuo Lv, Xiaohui Wang, Xiaohui Wang, Jingwen Liu, Jingwen Liu, Feng Wang, Feng Wang, Mingsheng Sun, Mingsheng Sun, Xueqiang Fan, Zhidong Ye, Peng Liu, Jianyan Wen   +13 more
doaj   +1 more source

Decreased Glucagon-Like Peptide-1 Is Associated With Calcific Aortic Valve Disease: GLP-1 Suppresses the Calcification of Aortic Valve Interstitial Cells

Frontiers in Cardiovascular Medicine, 2021
Objectives: This study explores the concentration and role of glucagon-like peptide-1 (GLP-1) in calcific aortic valve disease (CAVD).Background: Calcific aortic valve disease is a chronic disease presenting with aortic valve degeneration and ...
Fan Xiao, Qing Zha, Qianru Zhang, Qihong Wu, Zhongli Chen, Ying Yang, Ke Yang, Yan Liu   +7 more
doaj   +1 more source

A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification

JACC: Basic to Translational Science, 2022
Summary: Based on high-throughput transcriptomic sequencing, SNHG3 was among the most highly expressed long noncoding RNAs in calcific aortic valve disease. SNHG3 upregulation was verified in human and mouse calcified aortic valves. Moreover, in vivo and
Long Chen, MD, Hanning Liu, MD, PhD, Cheng Sun, MD, PhD, Jianqiu Pei, PhD, Jun Li, MD, Yue Li, PhD, Ke Wei, MD, PhD, Xiaoyi Wang, MD, Peng Wang, MD, Fangzhou Li, MD, Shujie Gai, MD, PhD, Yan Zhao, MD, Zhe Zheng, MD, PhD   +12 more
doaj   +1 more source

Biomarkers of Calcific Aortic Valve Disease [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Calcific aortic valve disease (CAVD) is a highly prevalent cardiovascular disorder accounting for a rising economic and social burden on aging populations. In spite of continuing study on the pathophysiology of disease, there remain no medical therapies to prevent the progression of CAVD.
Aeron, Small, Daniel, Kiss, Jay, Giri, Saif, Anwaruddin, Hasan, Siddiqi, Marie, Guerraty, Julio A, Chirinos, Giovanni, Ferrari, Daniel J, Rader   +8 more
openaire   +2 more sources