Results 21 to 30 of about 5,149,759 (252)

Palmdelphin Deficiency Evokes NF-κB Signaling in Valvular Endothelial Cells and Aggravates Aortic Valvular Remodeling

JACC: Basic to Translational Science, 2023
Summary: Palmd-deficient mice of advanced age manifest increased aortic valve peak velocity, thickened aortic valve leaflets, and excessive extracellular matrix deposition, which are key features of calcific aortic valve disease.
Yingchun Han, PhD, Jichao Zhang, MD, Zhao Yang, MD, Wen Jian, MD, Yuexin Zhu, PhD, Shijuan Gao, PhD, Yan Liu, PhD, Yingkai Li, MD, Songyuan He, MD, Congcong Zhang, MD, Yang Li, PhD, Bin You, MD, Jinghua Liu, MD, Jie Du, MD   +13 more
doaj   +1 more source

The Influence of Coronary Artery Disease in the Development of Aortic Stenosis and the Importance of the Albumin Redox State

Antioxidants, 2022
Calcific aortic valve and coronary artery diseases are related cardiovascular pathologies in which common processes lead to the calcification of the corresponding affected tissue.
Tamara Sastre-Oliva, Nerea Corbacho-Alonso, Diego Albo-Escalona, Juan A. Lopez, Luis F. Lopez-Almodovar, Jesús Vázquez, Luis R. Padial, Laura Mourino-Alvarez, Maria G. Barderas   +8 more
doaj   +1 more source

Clinical efficacy and safety of Cox-maze IV procedure for atrial fibrillation in patients with aortic valve calcification

Frontiers in Cardiovascular Medicine, 2023
ObjectiveAtrial fibrillation is associated with a high incidence of heart valve disease. There are few prospective clinical research comparing aortic valve replacement with and without surgical ablation for safety and effectiveness.
Ruikang Guo, Chengming Fan, Zhishan Sun, Hao Zhang, Yaqin Sun, Long Song, Zenan Jiang, Liming Liu   +7 more
doaj   +1 more source

Age, Sex, and Valve Phenotype Differences in Fibro‐Calcific Remodeling of Calcified Aortic Valve

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background In calcific aortic valve disease on tricuspid aortic valves (TAVs), men have higher aortic valve calcification and less fibrosis than women. However, little is known in bicuspid aortic valves (BAV).
Martine Voisine, Maxime Hervault, Mylène Shen, Anne‐Julie Boilard, Benoît Filion, Mickael Rosa, Yohan Bossé, Patrick Mathieu, Nancy Côté, Marie‐Annick Clavel   +9 more
doaj   +1 more source

Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview

Frontiers in Pharmacology, 2022
Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve interstitial cells.
Maria Bogdanova, Arsenii Zabirnyk, Arsenii Zabirnyk, Anna Malashicheva, Daria Semenova, John-Peder Escobar Kvitting, Mari-Liis Kaljusto, Maria del Mar Perez, Anna Kostareva, Anna Kostareva, Kåre-Olav Stensløkken, Gareth J Sullivan, Gareth J Sullivan, Gareth J Sullivan, Gareth J Sullivan, Gareth J Sullivan, Arkady Rutkovskiy, Arkady Rutkovskiy, Jarle Vaage, Jarle Vaage, Jarle Vaage   +20 more
doaj   +1 more source

Structure-function relationships in the aortic valve [PDF]

, 2012
PhDGlobally, heart valve dysfunction constitutes a large portion of the cardiovascular disease load, causing high rates of mortality in European and industrialized countries.
Anssari-Benam, Afshin
core   +4 more sources

Glycosaminoglycans affect endothelial to mesenchymal transformation, proliferation, and calcification in a 3D model of aortic valve disease

Frontiers in Cardiovascular Medicine, 2022
Calcific nodules form in the fibrosa layer of the aortic valve in calcific aortic valve disease (CAVD). Glycosaminoglycans (GAGs), which are normally found in the valve spongiosa, are located local to calcific nodules.
Jonathan Alejandro Bramsen, Bridget R. Alber, Melissa Mendoza, Bruce T. Murray, Mei-Hsiu Chen, Peter Huang, Gretchen J. Mahler   +6 more
doaj   +1 more source

Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro

International Journal of Cell Biology, 2020
Worldwide, calcific aortic valve disease is one of the leading causes of morbidity and mortality among patients with cardiac abnormalities. Aortic valve mineralization and calcification are the key events of adult calcific aortic valve disease ...
Anisha Polley, Riffat Khanam, Arunima Sengupta, Santanu Chakraborty   +3 more
doaj   +1 more source

Calcific Aortic Valve Disease: Cellular Origins of Valve Calcification [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
Calcific aortic valve disease is the most common indication for surgical valve replacement in the world.1 For years this disease was thought to be a passive degenerative phenomenon. Understanding of the cellular mechanisms of this valve lesion will present new cellular therapeutic options to slow disease progression.
openaire   +2 more sources

A case control investigation of the relation between hyperlipidaemia and calcific aortic valve stenosis [PDF]

, 1997
Objective To investigate the relation of hyperlipidaemia to calcific aortic valve stenosis. Design A case-control study designed to detect a clinically relevant difference in the fasting plasma concentrations of total cholesterol between the groups at ...
Stevenson, R N, Lord, John R, Wilmshurst, P T, Griffiths, H   +3 more
core   +1 more source