Results 81 to 90 of about 6,089 (248)

Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants

The Journal of Physiology, Volume 603, Issue 14, Page 3899-3922, 15 July 2025.
Abstract figure legend Dynamic interplay between the extracellular matrix (ECM) and vascular smooth muscle cells (VSMCs) in the medial layer of ascending thoracic aortic aneurysms (ATAA) associated with two variants: thickening (hypertrophic) and thinning (hypotrophic) aneurysm remodelling.
Berta H. Ganizada, Koen D. Reesink, Shaiv Parikh, Pepijn J. M. H. Saraber, Jack P. Cleutjens, Austin Isabella, Mathilde Q. E. Krebbekx, Armand M. Jaminon, Cecile F. M. Maassen, Mitch J. F. G. Ramaekers, Bart Spronck, Koen van der Laan, Rory R. Koenen, Roberto Lorusso, Jos G. Maessen, Elham Bidar, Leon J. Schurgers   +16 more
wiley   +1 more source

Management of Cardiovascular Health Issues in Turner Syndrome: Expert Insights and Expanded Recommendations From the 2024 Guideline Development Team

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 199, Issue 2, Page 51-71, June 2025.
ABSTRACT Turner syndrome (TS) is frequently complicated by congenital heart disease (CHD). While left‐sided lesions such as bicuspid aortic valve (BAV) and coarctation of the aorta are the most common structural heart lesions in TS, other anomalies, such as aortic arch malformations, hypoplastic left heart syndrome (HLHS), persistent left superior vena
Katya de Groote, Sheetal R. Patel, Kristian Havmand Mortensen, Isabel Witvrouwen, Anthonie Duijnhouwer, Nicole M. Brown, Jasmine Grewal, Kathryn C. Chatfield, Aaron T. Dorfman, Siddharth K. Prakash   +9 more
wiley   +1 more source

Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms

Brain and Behavior, Volume 15, Issue 5, May 2025.
Increased expression of LncRNA MIAT is associated with an elevated risk of intracranial aneurysm rupture. ABSTRACT Purpose: Intracranial aneurysm (IA) is characterized by localized dilation or ballooning of a blood vessel in the brain with life‐threatening consequences.
Fuquan Liu, Shuai Hao, Jingliyu Wang, Lei Chen, Ning Jiang, Laixing Liu, Xiangyi Wang   +6 more
wiley   +1 more source

Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy

iScience
Summary: Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS).
Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif   +3 more
doaj   +1 more source

The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta [PDF]

, 2019
Since the first observation of a helical flow pattern in aortic blood flow, the existence of helical blood flow has been found to be associated with various pathological conditions such as bicuspid aortic valve, aortic stenosis, and aortic dilatation ...
Ha, H, Kim, G.B, Kim, N, Kim, Y.-H, Kweon, J, Lee, S.J, Yang, D.H.   +6 more
core   +1 more source

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Angewandte Chemie International Edition, Volume 64, Issue 18, April 25, 2025.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt, Yassmine El Harraoui, Alex Rothemann, Adrian T. Jauch, Sigrid Müller‐Deubert, Martin F. Köllen, Timo Risch, Lianne JHC Jacobs, Rolf Müller, Franziska R. Traube, Denitsa Docheva, Stefan Zahler, Jan Riemer, Nina C. Bach, Stephan A. Sieber   +14 more
wiley   +1 more source

Válvula Aórtica Bicúspide en población pediátrica [PDF]

, 2017
La válvula aórtica bicúspide (VAB) es la cardiopatía congénita más frecuente. En muchas ocasiones esta patología es totalmente asintomática, pero se sabe que conlleva un no desdeñable número de complicaciones.
Blanco Fernández, Fabián
core  

Evaluation of face validity and core concepts of a novel knowledge scale for inherited heart disease: A pilot study

Journal of Genetic Counseling, Volume 34, Issue 2, April 2025.
Abstract The rising demand for genetic counseling has prompted the implementation of various innovative service delivery models, such as patient webinars, videos, chatbots, and the integration of genetic testing into mainstream healthcare. To ensure patients receive adequate information for informed decision‐making, validated measures to assess these ...
Susan Christian, Tara Dzwiniel, Amy Baker, Barbara Biesecker, Kennedy Borle, Roya Mostafavi, Jill Slamon, Hannah Wand, Laura Yeates   +8 more
wiley   +1 more source

Hemodynamic Measurement Using Four-Dimensional Phase-Contrast MRI: Quantification of Hemodynamic Parameters and Clinical Applications [PDF]

, 2019
Recent improvements have been made to the use of time-resolved, three-dimensional phase-contrast (PC) magnetic resonance imaging (MRI), which is also named four-dimensional (4D) PC-MRI or 4D flow MRI, in the investigation of spatial and temporal ...
Ha, H, Kim, GB, Kim, N, Kim, YH, Kweon, J, Lee, DH, Lee, SJ, Yang, DH   +7 more
core   +1 more source

Repeated Cranial and Large‐Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five‐Year Observational Study

ACR Open Rheumatology, Volume 7, Issue 3, March 2025.
Objective Giant cell arteritis (GCA) is characterized by cranial ischemia at diagnosis and late aortic structural disease. Repeated combined cranial and large‐vessel fluoro‐2‐deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scans were performed to assess the distribution of vasculitis activity over time and the ...
Anthony M. Sammel, Ivan Ho Shon, Daniel A. Moses, Stacey Fredericks, Gita Mathur, Claudia M. Hillenbrand, Edward Hsiao, Geoffrey Schembri, Rodger Laurent, Eva A. Wegner   +9 more
wiley   +1 more source