Results 41 to 50 of about 246,547 (300)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Apathy subtypes in acute stroke: validation of the Russian self-rated Dimensional Apathy Scale
The Egyptian Journal of Neurology, Psychiatry and NeurosurgeryBackground Apathy is a syndrome that can occur in a third of stroke patients. It can be measured by the Dimensional Apathy Scale (DAS), not yet utilized in acute stroke or translated to Russian.
Mansur Kutlubaev +2 more
doaj +1 more source
Non-pharmacologic interventions to treat apathy in Parkinson’s disease: A realist review
Clinical Parkinsonism & Related Disorders, 2021 Introduction: There is a diverse body of evidence investigating non-pharmacological treatment options for apathy in Parkinson’s disease (PD). We aimed to better understand the context and mechanisms by which non-pharmacological interventions may improve ...
Bria Mele +5 more
doaj +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
The translational study of apathy – an ecological approach
Frontiers in Behavioral Neuroscience, 2015 Apathy, a quantitative reduction in goal-directed behavior, is a prevalent symptom dimension with a negative impact on functional outcome in various neuropsychiatric disorders including schizophrenia and depression. The aim of this review is to show that
Flurin eCathomas +10 more
doaj +1 more source
Brain Stimulation, 2021 Background: Notwithstanding the large improvement in motor function in Parkinson’s disease (PD) patients treated with deep brain stimulation (DBS), apathy may increase.
Lennard I. Boon +13 more
doaj +1 more source
Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro +10 more
wiley +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
, 2000 Calls for a nationwide campaign to overcome civic apathy and outlines the framework for sustained, broad-based social change to restore America's civic ...
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Neuropsychiatric disturbances in atypical Parkinsonian disorders [PDF]
, 2018 Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are the most common atypical parkinsonisms. These disorders are characterized by varying combinations of autonomic, cerebellar and pyramidal system ...
Belvisi, Daniele +6 more
core +1 more source