Results 61 to 70 of about 246,547 (300)

Apathy dimensions in Parkinson's disease [PDF]

, 2018
OBJECTIVE: Apathy is a prominent and disabling symptom in Parkinson's disease (PD) and is a multidimensional behaviour, but which dimensions are specifically affected is unclear.
Benito-León, Brok, Brown, Castrioto, Dirnberger, Drijgers, Dujardin, Dujardin, Dujardin, Hoehn, Kay, Kirsch-Darrow, Laatu, Lawton, Leiknes, Leroi, Levy, Levy, Marin, Marin, Pagonabarraga, Pedersen, Pluck, Radakovic, Radakovic, Radakovic, Robert, Santangelo, Varanese, Wancata, Weintraub, Yesavage, Zis   +32 more
core   +2 more sources

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

A novel method for objective quantification of apathy based on gaze and physiological reactivity to stimuli presented in a virtual reality environment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We developed a tool for objective quantification of apathy. METHODS Participants (n = 97; 67 with cognitive impairment, 30 cognitively normal; mean age = 74.3 ± 6.2 years, 56.7% females) were exposed to emotional and cognitive stimuli in a ...
Ramit Ravona‐Springer, Or Koren, Noam Galor, Michal Lapid, Yotam Bahat, Ronen Fluss, Meytal Wilf, Shlomit Zorani, Uri Rosenblum, Michal Schnaider Beeri, Meir Plotnik   +10 more
doaj   +1 more source

Why the Apathy in American High Schools? [PDF]

, 1989
[Excerpt] Yes, it is a classic chicken versus egg problem. We assign teachers the responsibility for setting high standards but we do not give them any of the tools that might be effective for inducing student observance of the academic goals of the ...
Bishop, John H.
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

E-democracy: potential for political revolution? [PDF]

, 2003
This article focuses on the traditional notions of democracy and governance in the context of the recent shock first-round election results in France. The results prima facie suggest voter apathy and disengagement from the democratic process.
Mccullagh, K
core   +3 more sources

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

Post-stroke apathy: symptom profiles and association with cognitive impairment

Cerebral Circulation - Cognition and Behavior
Introduction: Post-stroke apathy is a debilitating behavioural syndrome affecting cognition, mood and outcome in about 35%-40% stroke survivors. Apathy is known to be associated with cognitive impairment and may be a prodromal symptom of vascular ...
Claudia Pallucca, Ratko Radakovic, Hugh Markus   +2 more
doaj   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Apathy in Alzheimer's disease: Contribution to a clinical view on progression of dementia

Dementia & Neuropsychologia
In addition to cognitive impairment, apathy is increasingly recognized as an important neuropsychiatric syndrome in Alzheimer's disease (AD). Aims: To identify the relationship between dementia severity and apathy levels, and to discuss the association ...
Florindo Stella, Larissa Pires de Andrade, Thays Martins Vital, Flávia Gomes de Melo Coelho, Carla Manuela Crispim Nascimento, Salma Stephany Soleman Hernández   +5 more
doaj   +1 more source