Results 261 to 270 of about 194,615 (302)

The Many Faces of the Tumor Suppressor Gene APC

Experimental Cell Research, 2001
Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer. Close examination of the function of APC has shown that it is a multifunctional protein involved in a wide variety of processes, including regulation of cell proliferation, cell migration, cell
Johan H VAN ES, Rachel H Giles, Hans C Clevers   +2 more
exaly   +4 more sources

Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene

Kaibogaku Zasshi Journal of Anatomy, 2005
The adenomatous polyposis coli (Apc) gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumors. The Apc gene product (APC), basically a cytoplasmic protein, blocks cell cycle progression and plays crucial roles in development.
Takao Senda, Atsushi Shimomura, Akiko Iizuka-Kogo   +2 more
exaly   +3 more sources

Purification of the Adenomatous Polyposis Coli (APC) Gene Product

Archives of Biochemistry and Biophysics, 1995
Mutation of the adenomatous polyposis coli (APC) gene is responsible for familial adenomatous polyposis and is an etiologic factor for digestive tract malignancies. Although the APC gene product (APC) is believed to play a role in growth suppression of colonocytes, the underlying mechanism is not clear. However, recent evidence does suggest that APC is
David M Wildrick, Bruce M Boman
exaly   +3 more sources

Identification of APC gene mutations in Italian APC patients by PCR-SSCP analysis

, 1993
The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer. It is also implicated in the development of sporadic colorectal tumors. The characterization of APC gene mutations in APC patients is clinically important because DNA-based tests can ...
L. Varesco, V. Gismondi, R. James, M. Robertson, P. Grammatico, J. Groden, L. Casarino, L. De Benedetti, A. Bafico, L. Bertario, P. Sala, PONZ DE LEON, Maurizio, R. Sassatelli, G. Biasco, A. Allegretti, H. Aste, S. De Sanctis, C. Rossetti, MT Illeni, A. Sciarra, G. Del Porto, R. White, GB Ferrara   +22 more
openaire   +2 more sources

The I1307K polymorphism of the APC gene in colorectal cancer

Gastroenterology, 1999
Colorectal cancer is one of the most frequent cancers in humans. Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews. However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon ...
Prior, T. W., Chadwick, R. B., Papp, A. C., Arcot, A. N., Isa, A. M., Pearl, D. K., Stemmermann, G., Percesepe, A., Loukola, A., Aaltonen, L. A., De la Chapelle, A.   +10 more
openaire   +3 more sources

Different Expressivity of two Adjacent Mutations of the APC Gene

Tumori Journal, 1999
Aims and background The phenotypic expression of different APC mutations in familial adenomatous polyposis (FAP) is variable: two to three variants of the disease have been defined based on the severity of colonic manifestations.
PRESCIUTTINI, SILVANO, Gismondi V, Scarcello E, Sala P, D'Elia F, Rossetti C, Caroti Ghelli C, Molina F, Groden J, MOSCA, FRANCO, Bertario L, Varesco L.   +11 more
openaire   +3 more sources

Study of the APC gene function in the mouse APC+/APC1638N model.

Neuro endocrinology letters, 2016
Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the presence of hundreds to thousands of benign polyps in the colon. If not removed prophylactically they represent a risk of developing malignant cancer with an almost 100% penentrance. FAP is induced by germline mutation in the APC gene.
Zuzana, Adamcikova, Lenka, Wachsmannova, Katarina, Hainova, Viola, Stevurkova, Vladimir, Holec, Sona, Ciernikova, Zuzana, Cierna, Pavol, Janega, Pavel, Babal, Michal, Mego, Vladimir, Zajac   +10 more
openaire   +1 more source

Association of the APC Gene Product with β-Catenin

Science, 1993
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was
B, Rubinfeld, B, Souza, I, Albert, O, Müller, S H, Chamberlain, F R, Masiarz, S, Munemitsu, P, Polakis   +7 more
openaire   +2 more sources

[The APC gene].

Nihon rinsho. Japanese journal of clinical medicine, 1996
The tumor suppressor gene APC is mutated in most cases of familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the APC gene is a 300 kDa protein present in the cytoplasm as a homodimer. Interestingly, the APC protein is known to interact with the adherence junction protein catenin, suggesting that APC may be involved in ...
openaire   +1 more source

Brain metastases exhibit gross deletions of the APC gene

Brain Tumor Pathology, 2011
Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragment length polymorphism method ...
Pećina-Šlaus, Nives, Nikuševa Martić, Tamara, Zeljko, Martina, Bulat, Sandra   +3 more
openaire   +3 more sources