Results 271 to 280 of about 194,615 (302)

APC Gene Expression in Gastric Carcinoma: An Immunohistochemical Study

Applied Immunohistochemistry & Molecular Morphology, 2002
Gastric carcinoma is one of the most common malignancies worldwide, particularly in Japan and China. Inactivation of the adenomatous polyposis coli ( ) gene, a tumor suppressor gene, has been shown to play a significant role in the development of colorectal carcinoma, and it has been suggested that it may play a role throughout the digestive tract ...
A, Grace, D, Butler, M, Gallagher, R, Al-Agha, Y, Xin, M, Leader, E, Kay   +6 more
openaire   +2 more sources

Biallelic inactivation of the APC gene in hepatoblastoma.

Cancer research, 1995
Familial adenomatous polyposis (FAP) is an inherited disorder caused by germline mutation of the adenomatous polyposis coli (APC) gene. Increased risk of hepatoblastoma (HBL) in FAP kindreds has been reported. To determine whether inactivation of the APC gene plays a role in development of HBL, 13 sporadic infantile hepatic tumors were analyzed for ...
H, Kurahashi, K, Takami, T, Oue, T, Kusafuka, A, Okada, A, Tawa, S, Okada, I, Nishisho   +7 more
openaire   +1 more source

Mutations in the APC gene and their implications for protein structure and function

Current Opinion in Genetics & Development, 1995
An enormous number of germline and somatic mutations have been identified in the APC tumor suppressor gene. Nearly all of these mutations result in premature polypeptide chain termination, but the consequences to APC protein function are unknown. Recent advances, including the identification of an oligomerization domain, the localization of several ...
openaire   +2 more sources

The APC gene product and colorectal carcinogenesis.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1997
The adenomatous polyposis coli (APC) gene has been found to be mutated during the development of sporadic colorectal tumours as well as in familial adenomatous polyposis patients (FAP), mutations being somatic or germinal respectively. The gene product is truncated in the carboxyterminal region but the role of the APC protein in tumorigenesis is not ...
C, Bonneton, L, Larue, J P, Thiéry
openaire   +1 more source

APC gene and molecular diagnostics

2003
Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
openaire  

Four novel germline mutations of the APC gene

Human Mutation, 1996
D, Wells, P, Chapman, J C, Landgrebe, K, Tsioupra, J D, Delhanty   +4 more
openaire   +2 more sources

Mutated APC Gene

Advances in Anatomic Pathology, 1994
openaire   +1 more source

Hepatoblastoma as a Result of APC Gene Mutation

Journal of Pediatric Gastroenterology and Nutrition, 2012
Maryna, Krawczuk-Rybak, Anna, Jakubiuk-Tomaszuk, Elzbieta, Skiba, Andrzej, Plawski   +3 more
openaire   +2 more sources

Alterations of Adenomatous Polyposis Coli (APC) gene in oral squamous cell carcinoma

International Journal of Oral and Maxillofacial Surgery, 2000
Kuo-Wei Chang, Shu-Chun Lin, Che-Shoa Chang   +2 more
exaly   +2 more sources

APC gene and presimptomatic genetic testing

2003
Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
openaire