Results 61 to 70 of about 7,079 (169)

Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization

Scientific Reports, 2021
The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +3 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Evaluation of Serum Apelin-13 in Acne Vulgaris Patients [PDF]

Benha Journal of Applied Sciences, 2018
Acne is a longstanding inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles by Propionibacterium acne [1]. Apelin is a newely discovered adipocytokine secreted by white adipose tissue and couples with the APJ receptor
N.E. Sorour, N.A. Abdalhafeez, E.M. Akl, M. Abd El-wahed   +3 more
openaire   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Molecular profile of pediatric pseudotumor cerebri: the role of apelin isoforms and oxidative stress

BMC Pediatrics
Background Apelin is an endogenous ligand of the apelin receptor (APJ), expressed in multiple tissues, including the brain and heart. Isoforms such as apelin-13 and apelin-36 play protective roles in pathological processes, including oxidative stress ...
Peren Perk, Arzu Yuksel, Zeynep Oz Dagdelen, Sevinc Mertoglu, Merve Cakmak, Pakize Cennetoglu, Pınar Arıcan, Alper Gumus, Ihsan Kafadar   +8 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang, Qijian Zhao, Yufei Wu, Keqiang Shu, Junye Chen, Kang Li, Yuyao Feng, Xu Zhang, Wenjian Liu, Zhichao Lai, Bao Liu   +10 more
wiley   +1 more source

Preferential apelin‐13 production by the proprotein convertase PCSK3 is implicated in obesity

FEBS Open Bio, 2013
The peptide hormone apelin is translated as a 77‐residue preproprotein, truncated to the 55‐residue proapelin and, subsequently, to 13–36‐residue bioactive isoforms named apelin‐13 to ‐36. Proapelin is hypothesized to be cleaved to apelin‐36 and then to the shorter isoforms.
Shin, Kyungsoo, Pandey, Aditya, Liu, Xiang-Qin, Anini, Younes, Rainey, Jan K.   +4 more
openaire   +2 more sources

Role of Triceps Muscle Fiber‐Specific Myokines in Pancreatic β‐Cell Protection: Implications for Type 2 Diabetes: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague, Dujardin Makeda, Hermann Yokolo, Joshua Ekouo   +3 more
wiley   +1 more source

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in
Jeremy B. Ducharme, Martin M. Schonk, Miguel A. Gutierrez‐Monreal, Leonardo F. Ferreira, Karyn A. Esser, Andrew R. Judge, Sarah M. Judge   +6 more
wiley   +1 more source