Results 81 to 90 of about 23,711 (313)
The role of apelin in the retina of diabetic rats. [PDF]
PLoS ONE, 2013 PURPOSE: Apelin is a novel adipocytokine participating in diabetes, but its role in diabetic retinopathy (DR) is unknown. Our study aimed to investigate the effect of apelin on the proliferative potential in DR along with its antagonist inhibitory ...
Qiang Lu, Jing Feng, Yan-Rong Jiang
doaj +1 more source
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice [PDF]
, 2015 Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus ...
Arisi, I +14 more
core +4 more sources
Stem Cells International, 2022 Although mesenchymal stem cell- (MSC-) based therapy has shown promising results for myocardial infarction (MI), low cell survival heavily limits its beneficial effects. Apelin plays an essential regulatory role in cell proliferation.
Guona Chen +11 more
semanticscholar +1 more source
Apelin promotes lymphangiogenesis and lymph node metastasis [PDF]
, 2014 International ...
Berger, Walter +15 more
core +3 more sources
Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017 Apelin is a peptide ligand for a class A G-protein coupled receptor called the apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and cardiovascular functions. Apelin has been shown to be bioactive as 13, 17, and 36 amino acid isoforms, C-terminal fragments of the putatively inactive 55-residue proprotein (proapelin or ...
Kyungsoo Shin +8 more
openaire +3 more sources
Apelin as a new therapeutic target for COVID-19 treatment
QJM : monthly journal of the Association of Physicians, 2022 Background Apelin is an endogenous neuropeptide that binds to the G-protein-coupled receptor (APJ) and participates in a variety of physiological processes in the heart, lungs and other peripheral organs.
Jiwon Park +5 more
semanticscholar +1 more source
Animal Research and One Health, EarlyView.Dietary supplement of sodium butyrate, may relate to regulating intestinal health and thus the growth performance and meat quality of rabbits by regulating the continuous process of promoting the periodic cycle of cecal epithelial cells. Abstract Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth ...
Mengke Ni +8 more
wiley +1 more source
The apelinergic system in the developing lung: expression and signaling [PDF]
, 2011 Apelin and its receptor APJ constitute a signaling pathway best recognized as an important regulator of cardiovascular homeostasis. This multifunctional peptidergic system is currently being described to be involved in embryonic events which extend into ...
Moura, Rute S. +3 more
core +1 more source
Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C
Mediators of Inflammation, 2011 Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to ...
Hala O. El-Mesallamy +3 more
doaj +1 more source
Journal of Clinical and Translational Science, 2017 OBJECTIVES/SPECIFIC AIMS: Women with pulmonary arterial hypertension (PAH) exhibit superior right ventricular (RV) function and survival compared with men, a phenomenon attributed to poorly understood cardioprotective effects of 17β-estradiol (E2).
Andrea Lee Frump +7 more
doaj +1 more source