Results 11 to 20 of about 2,955 (177)

Virus isolate from carp: genetic characterization reveals a novel picornavirus with two aphthovirus 2A-like sequences

Journal of General Virology, 2014
Picornaviruses have been isolated from a variety of hosts, mainly mammals and birds. Here, we describe the sequence analysis of carp picornavirus 1 (CPV-1) F37/06 that was isolated from an organ pool (heart, brain, liver) of a common carp (Cyprinus carpio). This carp perished after an accidental discharge of liquid manure into a fish pond and presented
Jeannette, Lange, Marco, Groth, Dieter, Fichtner, Harald, Granzow, Barbara, Keller, Mario, Walther, Matthias, Platzer, Andreas, Sauerbrei, Roland, Zell   +8 more
openaire   +3 more sources

Deletion or substitution of the aphthovirus 3′ NCR abrogates infectivity and virus replication

Journal of General Virology, 2001
The 3′ noncoding region (NCR) of the genomic picornaviral RNA is believed to contain majorcis-acting signals required for negative-strand RNA synthesis. The 3′ NCR of foot-and-mouth disease virus (FMDV) was studied in the context of a full-length infectious clone in which the genetic element was deleted or exchanged for the equivalent region of a ...
Sáiz, M., Gómez, S., Martínez-Salas, E., Sobrino, F.   +3 more
openaire   +5 more sources

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication [PDF]

Journal of Virology
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupting replication
You Li, Xin Zheng, Ling Xie, Maryna Kapustina, Takayoshi Shirasaki, Bryan Yonish, Xian Chen, Asuka Hirai-Yuki, Noriyo Nagata, Ryosuke Suzuki, Masanori Isogawa, Matthew R. Vogt, Masamichi Muramatsu, Stanley M. Lemon   +13 more
doaj   +2 more sources

Foot-and-mouth disease in Asia

Virus Research
Foot-and-mouth disease (FMD) is a highly contagious transboundary disease prevalent across the Asian continent, affecting both wild and domestic artiodactyls.
Md. Abdur Rahman, Farah Zereen, Md. Liton Rana, Md. Golzar Hossain, Masaru Shimada, Sukumar Saha   +5 more
doaj   +2 more sources

Persistence and chronic urinary shedding of the aphthovirus equine rhinitis A virus

Journal of Equine Veterinary Science, 2012
Equine rhinitis A virus (ERAV) is a member of the Aphthovirus genus, and has many physical and structural similarities to the prototype Aphthovirus foot-and-mouth disease virus (FMDV). The pathogenesis of FMDV has been extensively studied, however, the similarities in the pathogenesis of ERAV and FMDV disease has not been well documented.
Stacey E, Lynch, James R, Gilkerson, Sally J, Symes, Jin-an, Huang, Carol A, Hartley   +4 more
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Cryo-EM structure of the Seneca Valley virus A-particle and related structural states [PDF]

Journal of Virology
Picornavirus cell entry requires a series of capsid protein conformational changes leading to genome uncoating. For enteroviruses, receptor binding triggers the transition from a full (F) capsid to an altered (A) particle before releasing its genome and ...
Rosheny Kumaran, Nadishka Jayawardena, Kuan-Lin Chen, Alice-Roza Eruera, James Hodgkinson-Bean, Laura N. Burga, Matthias Wolf, Mihnea Bostina   +7 more
doaj   +2 more sources

Molecular characterization of VP1 gene during the foot and mouth disease virus outbreak in East Java, Indonesia, in 2022 [PDF]

Veterinary World
Background and Aim: Foot and mouth disease (FMD) is highly contagious in cloven-hoofed animals, and it causes outbreaks in Indonesia and several countries worldwide.
Zayyin Dinana, Suwarno Suwarno, Imam Mustofa, Jola Rahmahani, Kusnoto Kusnoto, Aussie Tahta Maharani, Anisa Lailatul Fitria, Adiana Mutamsari Witaningrum, Firdausy Kurnia Maulana, Nur Saidah Said, Deka Uli Fahrodi, Fedik Abdul Rantam   +11 more
doaj   +2 more sources

Parameters influencing translational efficiency in aphthovirus IRES-based bicistronic expression vectors

Gene, 1998
Initiation of translation in picornavirus RNAs occurs internally, mediated by an internal ribosome entry site (IRES) element. This property has been exploited to coexpress proteins from a single bicistronic transcription unit in eukaryotic cells. The region that separates the IRES element from the authentic initiator codon of the second gene plays an ...
S, López de Quinto, E, Martínez-Salas
openaire   +3 more sources

Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’

Journal of General Virology, 2001
The 2A region of the aphthovirus foot-and-mouth disease virus (FMDV) polyprotein is only 18 aa long. A ‘primary’ intramolecular polyprotein processing event mediated by 2A occurs at its own C terminus. FMDV 2A activity was studied in artificial polyproteins in which sequences encoding reporter proteins flanked the 2A sequence such that a single, long ...
Michelle L L, Donnelly, Garry, Luke, Amit, Mehrotra, Xuejun, Li, Lorraine E, Hughes, David, Gani, Martin D, Ryan   +6 more
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Studies of Aphthovirus Subunits and Synthetic Peptides Relevant to Their Use as Vaccines Against Foot and Mouth Disease.

, 1986
Laboratory animals and cattle were vaccinated with the aphthovirus capsid protein VPl or with aphthovirus-specific synthetic peptides. The peptides used copied either the sequence of amino-acids 141-160 from the VPl of aphthovirus strains OlBFS 1860 and 01 Kaufbeuren (the 0 peptide) or the equivalent sequence from aphthovirus strain A24 Cruzeiro (the A
Murdin, Andrew David.
openaire   +2 more sources