Results 11 to 20 of about 2,793 (153)

Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

PLoS Pathogens, 2009
Equine rhinitis A virus (ERAV) is closely related to foot-and-mouth disease virus (FMDV), belonging to the genus Aphthovirus of the Picornaviridae. How picornaviruses introduce their RNA genome into the cytoplasm of the host cell to initiate replication ...
Tobias J Tuthill, Karl Harlos, Thomas S Walter, Nick J Knowles, Elisabetta Groppelli, David J Rowlands, David I Stuart, Elizabeth E Fry   +7 more
doaj   +4 more sources

Assessment of Foot-and-Mouth Disease Trends in Türkiye Between 2005 and 2025. [PDF]

Transbound Emerg Dis
Foot‐and‐mouth disease (FMD) is a highly contagious viral illness that continues to threaten livestock health, productivity, and trade, particularly in countries like Türkiye where multiple FMD serotypes cocirculate. This study aimed to analyze the temporal and spatial distributions, serotype dynamics, and seasonal patterns of FMD in Türkiye between ...
Pedro Mil-Homens M, Arede M, Beltrán-Alcrudo D, Hovari M, Raizman E, Allepuz Palau A.   +5 more
europepmc   +2 more sources

Involvement of the Aphthovirus RNA Region Located between the Two Functional AUGs in Start Codon Selection

Virology, 1999
Initiation of translation in picornavirus RNAs occurs internally, mediated by an element termed internal ribosome entry site (IRES). In the aphthovirus RNA, the IRES element directs translation initiation at two in-frame AUGs separated by 84 nucleotides.
Encarna Martínez-Salas, Sonia Lopez De Quinto   +1 more
exaly   +3 more sources

Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs

Nucleic Acids Research, 1989
An analysis of published nucleotide sequences of the 5'-untranslated region (5'-UTR) of 7 cardioviruses and 3 aphthoviruses has allowed us to derive a consensus secondary structure model that differs from that previously proposed for the 5'-UTR of entero- and rhinoviruses, though all these viruses belong to the same family, Picornaviridae.
Vadim Agol, V I Agol, V M Blinov
exaly   +4 more sources

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication [PDF]

Journal of Virology
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupting replication
You Li, Xin Zheng, Ling Xie, Maryna Kapustina, Takayoshi Shirasaki, Bryan Yonish, Xian Chen, Asuka Hirai-Yuki, Noriyo Nagata, Ryosuke Suzuki, Masanori Isogawa, Matthew R. Vogt, Masamichi Muramatsu, Stanley M. Lemon   +13 more
doaj   +2 more sources

Oral and Faecal Viromes of New Zealand Calves on Pasture With an Idiopathic Ill-Thrift Syndrome. [PDF]

Transbound Emerg Dis
Since 2015, an idiopathic ill‐thrift syndrome featuring diarrhoea and, in some cases, gastrointestinal ulceration has been reported in weaned New Zealand dairy calves. Similar syndromes have been described in the British Isles and Australia, but investigations in New Zealand have yet to identify a specific cause. Notably, the viromes of affected calves
Grimwood RM, Darnley JA, O'Connell JP, Hunt H, Taylor HS, Lawrence KE, Abbott MBW, Jauregui R, Geoghegan JL.   +8 more
europepmc   +2 more sources

Conserved tertiary structural elements in the 5’ nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs

Nucleic Acids Research, 1993
Statistical analyses of RNA folding in 5' nontranslated regions (5'NTR) of encephalomyocarditis virus, Theiler's murine encephalomyelitis virus, foot-and-mouth disease virus, and hepatitis A virus indicate that two highly significant folding regions occur in the 5' and 3' portions of the 5'NTR.
Nahum Sonenberg, Shu-Yun Le, Jih-H Chen   +2 more
exaly   +4 more sources

Serotype Diversity and Molecular Characterization of Foot-and-Mouth Disease Viruses From Outbreaks in Ethiopia (2019-2023): Re-Emergence of SAT 2 After 30 Years. [PDF]

Transbound Emerg Dis
Ethiopia faces significant economic losses from foot‐and‐mouth disease (FMD). Laboratory diagnostic tools such as antigen detection ELISA (Ag‐ELISA), reverse transcription polymerase chain reaction (RT‐PCR), and sequencing provide important information that underpin control initiatives.
Gizaw D, Senbata B, Fentie A, Bilata T, Negessu D, Muluneh A, Shegu D, Ashenafi H, Knowles NJ, Wadsworth J, Mioulet V, Hicks HM, Legesse M, Kassa T, King DP.   +14 more
europepmc   +2 more sources

Molecular characterization of VP1 gene during the foot and mouth disease virus outbreak in East Java, Indonesia, in 2022 [PDF]

Veterinary World
Background and Aim: Foot and mouth disease (FMD) is highly contagious in cloven-hoofed animals, and it causes outbreaks in Indonesia and several countries worldwide.
Zayyin Dinana, Suwarno Suwarno, Imam Mustofa, Jola Rahmahani, Kusnoto Kusnoto, Aussie Tahta Maharani, Anisa Lailatul Fitria, Adiana Mutamsari Witaningrum, Firdausy Kurnia Maulana, Nur Saidah Said, Deka Uli Fahrodi, Fedik Abdul Rantam   +11 more
doaj   +2 more sources

Cryo-EM structure of the Seneca Valley virus A-particle and related structural states [PDF]

Journal of Virology
Picornavirus cell entry requires a series of capsid protein conformational changes leading to genome uncoating. For enteroviruses, receptor binding triggers the transition from a full (F) capsid to an altered (A) particle before releasing its genome and ...
Rosheny Kumaran, Nadishka Jayawardena, Kuan-Lin Chen, Alice-Roza Eruera, James Hodgkinson-Bean, Laura N. Burga, Matthias Wolf, Mihnea Bostina   +7 more
doaj   +2 more sources