Results 21 to 30 of about 1,890 (161)

Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution [PDF]

Journal of Virology, 1996
Translation of aphthovirus RNA is initiated at an internal ribosome entry site (IRES) element, preceding the first functional AUG initiation codon. The effect of mutations at the base of domain 3 of the aphthovirus IRES on translation activity has been analyzed by site-directed mutagenesis and expression of bicistronic RNAs in transfected cells.
Encarnación Martı́nez-Salas, Maria Paz Regalado, Esteban Domingo   +2 more
semanticscholar   +5 more sources

Behavior of intertypic recombinants between virulent and attenuated aphthovirus strains in tissue culture and cattle [PDF]

Journal of Virology, 1988
Two aphthovirus intertypic recombinants between the virulent strain A Venceslau and guanidine-resistant attenuated mutants of either strain C3 Resende or O1 Campos were obtained in an attempt to establish the region(s) of the viral genome responsible for attenuation in cattle. Recombinants that inherited the 3' half of the genome from either attenuated
Ana T. Giraudo, I. Gomes, P A de Mello, Ewald Beck, J.L. La Torre, Eduardo A. Scodeller, Ingrid E. Bergmann   +6 more
semanticscholar   +4 more sources

Aphthovirus

Definitions, 2011
This datasheet on Aphthovirus covers Identity, Distribution, Hosts/Species Affected.
Marvin J. Grubman, Teresa de los Santos
semanticscholar   +3 more sources

Cell Recognition by Foot-and-Mouth Disease Virus That Lacks the RGD Integrin-Binding Motif: Flexibility in Aphthovirus Receptor Usage [PDF]

Journal of Virology, 2000
ABSTRACT Cell surface molecules that can act as virus receptors may exert an important selective pressure on RNA viral quasispecies. Large population passages of foot-and-mouth disease virus (FMDV) in cell culture select for mutant viruses that render dispensable a highly conserved Arg-Gly-Asp (RGD) motif responsible for integrin
Éric Baranowski, Carmen M. Ruiz-Jarabo, Noemı́ Sevilla, David Andreu, Ewald Beck, Esteban Domingo   +5 more
semanticscholar   +6 more sources

Specific inhibition of aphthovirus infection by RNAs transcribed from both the 5' and the 3' noncoding regions [PDF]

Journal of Virology, 1994
RNA molecules containing the 3' terminal region of foot-and-mouth disease virus (FMDV) RNA in both antisense and sense orientations were able to inhibit viral FMDV translation and infective particle formation in BHK-21 cells following comicroinjection or cotransfection with infectious viral RNA.
Alfonso Gutiérrez‐Adán, Encarnación Martı́nez-Salas, Belén Pintado, Francisco Sobrino   +3 more
semanticscholar   +6 more sources

Conserved tertiary structural elements in the 5’ nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs

Nucleic Acids Research, 1993
Statistical analyses of RNA folding in 5' nontranslated regions (5'NTR) of encephalomyocarditis virus, Theiler's murine encephalomyelitis virus, foot-and-mouth disease virus, and hepatitis A virus indicate that two highly significant folding regions occur in the 5' and 3' portions of the 5'NTR.
Shu‐Yun Le, Jih-H. Chen, Nahum Sonenberg, Jacob V. Maizel   +3 more
semanticscholar   +6 more sources

The cleavage activities of aphthovirus and cardiovirus 2A proteins.

Journal of General Virology, 1997
The primary 2A/2B polyprotein cleavage of aphtho-and cardioviruses is mediated by their 2A proteins cleaving C-terminally. Whilst the aphthovirus 2A region is only 16 aa (possibly 18 aa) long, the cardiovirus 2A protein is some 150 aa. We have previously shown that foot-and-mouth disease virus (FMDV) 2A is able to mediate cleavage in an artificial ...
Michelle Donnelly, Martin D. Ryan, Mike Flint, David Gani, Sean J. Monaghan   +4 more
semanticscholar   +4 more sources

Involvement of the Aphthovirus RNA Region Located between the Two Functional AUGs in Start Codon Selection

Virology, 1999
Initiation of translation in picornavirus RNAs occurs internally, mediated by an element termed internal ribosome entry site (IRES). In the aphthovirus RNA, the IRES element directs translation initiation at two in-frame AUGs separated by 84 nucleotides.
Sonia López de Quinto, Encarnación Martı́nez-Salas   +1 more
semanticscholar   +4 more sources

Heterogeneity of the polyribocytidylic acid tract in aphthovirus: biochemical and biological studies of viruses carrying polyribocytidylic acid tracts of different lengths [PDF]

Journal of Virology, 1984
In this paper we report a study of a sample of foot-and-mouth disease virus carrying two polyribocytidylic acid [poly(C)] tracts of different lengths. By plaque purification in tissue culture, we isolated two populations of particles, one carrying the long poly(C) tract and the other carrying only the short homopolymer. The fingerprints of both viruses
M.P. Costa Giomi, Ingrid E. Bergmann, Eduardo A. Scodeller, P Augé de Mello, Isabelle Gomez, J.L. La Torre   +5 more
semanticscholar   +4 more sources

Deletion or substitution of the aphthovirus 3′ NCR abrogates infectivity and virus replication

Journal of General Virology, 2001
The 3′ noncoding region (NCR) of the genomic picornaviral RNA is believed to contain majorcis-acting signals required for negative-strand RNA synthesis. The 3′ NCR of foot-and-mouth disease virus (FMDV) was studied in the context of a full-length infectious clone in which the genetic element was deleted or exchanged for the equivalent region of a ...
Margarita Sáiz, Sandra Gómez, Encarnación Martı́nez-Salas, Francisco Sobrino   +3 more
semanticscholar   +6 more sources