Results 31 to 40 of about 4,184 (207)

Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo

RNA, 2000
The strategies developed by internal ribosome entry site (IRES) elements to recruit the translational machinery are poorly understood. In this study we show that protein-RNA interaction of the eIF4G translation initiation factor with sequences of the foot-and-mouth disease virus (FMDV) IRES is a key determinant of internal translation initiation in ...
Sonia López de Quinto, Encarnación Martı́nez-Salas   +1 more
openalex   +4 more sources

Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs

Nucleic Acids Research, 1989
An analysis of published nucleotide sequences of the 5'-untranslated region (5'-UTR) of 7 cardioviruses and 3 aphthoviruses has allowed us to derive a consensus secondary structure model that differs from that previously proposed for the 5'-UTR of entero- and rhinoviruses, though all these viruses belong to the same family, Picornaviridae.
Evgeny V. Pilipenko, Vladimir M. Blinov, B. K. Chernov, T. M. Dmitrieva, Vadim I. Agol   +4 more
openalex   +5 more sources

Deletion or substitution of the aphthovirus 3′ NCR abrogates infectivity and virus replication

Journal of General Virology, 2001
The 3′ noncoding region (NCR) of the genomic picornaviral RNA is believed to contain majorcis-acting signals required for negative-strand RNA synthesis. The 3′ NCR of foot-and-mouth disease virus (FMDV) was studied in the context of a full-length infectious clone in which the genetic element was deleted or exchanged for the equivalent region of a ...
Margarita Sáiz, Sandra Gómez, Encarnación Martı́nez-Salas, Francisco Sobrino   +3 more
openalex   +4 more sources

Molecular characterization of VP1 gene during the foot and mouth disease virus outbreak in East Java, Indonesia, in 2022 [PDF]

Veterinary World
Background and Aim: Foot and mouth disease (FMD) is highly contagious in cloven-hoofed animals, and it causes outbreaks in Indonesia and several countries worldwide.
Zayyin Dinana, Suwarno Suwarno, Imam Mustofa, Jola Rahmahani, Kusnoto Kusnoto, Aussie Tahta Maharani, Anisa Lailatul Fitria, Adiana Mutamsari Witaningrum, Firdausy Kurnia Maulana, Nur Saidah Said, Deka Uli Fahrodi, Fedik Abdul Rantam   +11 more
doaj   +2 more sources

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication [PDF]

Journal of Virology
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupting replication
You Li, Xin Zheng, Ling Xie, Maryna Kapustina, Takayoshi Shirasaki, Bryan Yonish, Xian Chen, Asuka Hirai-Yuki, Noriyo Nagata, Ryosuke Suzuki, Masanori Isogawa, Matthew R. Vogt, Masamichi Muramatsu, Stanley M. Lemon   +13 more
doaj   +2 more sources

Heterogeneity of the polyribocytidylic acid tract in aphthovirus: biochemical and biological studies of viruses carrying polyribocytidylic acid tracts of different lengths [PDF]

Journal of Virology, 1984
In this paper we report a study of a sample of foot-and-mouth disease virus carrying two polyribocytidylic acid [poly(C)] tracts of different lengths. By plaque purification in tissue culture, we isolated two populations of particles, one carrying the long poly(C) tract and the other carrying only the short homopolymer. The fingerprints of both viruses
M.P. Costa Giomi, Ingrid E. Bergmann, Eduardo A. Scodeller, P Augé de Mello, Isabelle Gomez, J.L. La Torre   +5 more
openalex   +3 more sources

Four Independent Antigenic Determinants on the Capsid Polypeptides of Aphthovirus

Journal of General Virology, 1983
Four independent antigenic determinants in the virus capsid have been defined in radioimmunoassay tests using antisera prepared against isolated structural polypeptides VP1, 2 and 3. Only one determinant was detected on the intact particle and it was contained within VP1 (called the VP1-A determinant).
J. M. Haresnape, D. McCahon
openalex   +3 more sources

Cryo-EM structure of the Seneca Valley virus A-particle and related structural states [PDF]

Journal of Virology
Picornavirus cell entry requires a series of capsid protein conformational changes leading to genome uncoating. For enteroviruses, receptor binding triggers the transition from a full (F) capsid to an altered (A) particle before releasing its genome and ...
Rosheny Kumaran, Nadishka Jayawardena, Kuan-Lin Chen, Alice-Roza Eruera, James Hodgkinson-Bean, Laura N. Burga, Matthias Wolf, Mihnea Bostina   +7 more
doaj   +2 more sources

Location of an Immunizing Determinant within Polypeptide VP1 of Type O Aphthovirus

Journal of General Virology, 1983
VP1 is the only structural polypeptide of aphthovirus able to stimulate the production of neutralizing antibody. The region of VP1 responsible for this activity was located by testing various proteolytic fragments of VP1 for their ability to compete for virus-specific antibodies in serum raised against the intact polypeptide.
J. M. Haresnape, Andrew M. Q. King, D. McCahon   +2 more
openalex   +3 more sources

Involvement of the Aphthovirus RNA Region Located between the Two Functional AUGs in Start Codon Selection

Virology, 1999
Initiation of translation in picornavirus RNAs occurs internally, mediated by an element termed internal ribosome entry site (IRES). In the aphthovirus RNA, the IRES element directs translation initiation at two in-frame AUGs separated by 84 nucleotides.
Sonia López de Quinto, Encarnación Martı́nez-Salas   +1 more
openalex   +3 more sources