Uncoupling apical constriction from tissue invagination [PDF]
eLife, 2017 Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular ...
SeYeon Chung +2 more
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Wnt-dependent mechanism of the apical constriction of roof plate cells in developing mouse spinal cord [PDF]
Frontiers in Cell and Developmental BiologyApical constriction of epithelial cells usually occurs in a local portion of epithelial sheet, which results in bending of epithelial tissues. However, it is uncertain whether diffusible signal molecules, like Wnt, regulate such locally restricted events.
Tadashi Okubo +2 more
exaly +7 more sources
Apical constriction and epithelial invagination are regulated by BMP activity [PDF]
Biology Open, 2015 Epithelial invagination is a morphological process in which flat cell sheets transform into three-dimensional structures through bending of the tissue. It is accompanied by apical constriction, in which the apical cell surface is reduced in relation to ...
Vijay K. Jidigam +3 more
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Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation [PDF]
eLife, 2023 Apical constriction is a basic mechanism for epithelial morphogenesis, making columnar cells into wedge shape and bending a flat cell sheet. It has long been thought that an apically localized myosin generates a contractile force and drives the cell ...
Satoshi Yamashita +2 more
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Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction. [PDF]
PLoS Genetics, 2023 One of the most common cell shape changes driving morphogenesis in diverse animals is the constriction of the apical cell surface. Apical constriction depends on contraction of an actomyosin network in the apical cell cortex, but such actomyosin networks
Mark M Slabodnick +10 more
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Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling [PDF]
Nature Communications, 2023 Apical constriction is known to be critical for neural tube closure, but the signals that induce this process have not been fully characterized. Here Yoon et al.
Jaeho Yoon +4 more
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Alpha-Catulin, a New Player in a Rho Dependent Apical Constriction That Contributes to the Mouse Neural Tube Closure [PDF]
Frontiers in Cell and Developmental Biology, 2020 Coordination of actomyosin contraction and cell-cell junctions generates forces that can lead to tissue morphogenetic processes like the formation of neural tube (NT), however, its molecular mechanisms responsible for regulating and coupling this ...
Agnieszka Kobielak +2 more
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Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues [PDF]
Nature Communications, 2022 Apical constriction is a force-generating process required during embryonic development; there is a lack of tools to manipulate 3D shapes of mammalian tissues.
Guillermo Martínez-Ara +9 more
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Assays for Apical Constriction Using the Xenopus Model. [PDF]
Methods Mol Biol, 2022 Apical constriction refers to the active, actomyosin-driven process that reduces apical cell surface area in epithelial cells. Apical constriction is utilized in epithelial morphogenesis during embryonic development in multiple contexts, such as gastrulation, neural tube closure, and organogenesis.
Baldwin AT +3 more
europepmc +3 more sources
Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction. [PDF]
J Cell Biol, 2022 Abstract During tissue morphogenesis, cell shape changes resulting from cell-generated forces often require active regulation of intracellular trafficking. How mechanical stimuli influence intracellular trafficking and how such regulation impacts tissue mechanics are not fully understood. In this study, we identify an
Chen W, He B.
europepmc +4 more sources