A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT [PDF]
eLife, 2023 Epithelial-to-mesenchymal transition (EMT) is a fundamental process whereby epithelial cells acquire mesenchymal phenotypes and the ability to migrate. EMT is the hallmark of gastrulation, an evolutionarily conserved developmental process.
Alexandre Francou +2 more
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Cell-Autonomous Ca2+ Flashes Elicit Pulsed Contractions of an Apical Actin Network to Drive Apical Constriction during Neural Tube Closure [PDF]
Cell Reports, 2015 Neurulation is a critical period in all vertebrates and results in the formation of the neural tube, which gives rise to the CNS. Apical constriction is one of the fundamental morphogenetic movements that drives neural tube closure.
Neophytos Christodoulou +1 more
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Actin and Apical Constriction: Some (Re)-Assembly Required [PDF]
Developmental Cell, 2015 Linkage of the actomyosin cytoskeleton to cell-cell junctions drives cell shape change in development and homeostasis. In this issue of Developmental Cell, Jodoin et al. (2015) provide new insights into the underlying mechanisms, revealing that factors driving actin filament disassembly and thus dynamics also play key roles in apical constriction.
Spracklen, Andrew J., Peifer, Mark
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Apical domain polarization localizes actin–myosin activity to drive ratchet-like apical constriction [PDF]
Nature Cell Biology, 2013 Apical constriction promotes epithelia folding, which changes tissue architecture. During Drosophila gastrulation, mesoderm cells exhibit repeated contractile pulses that are stabilized such that cells apically constrict like a ratchet. The transcription factor Twist is required to stabilize cell shape.
Tworoger, Michael B. +2 more
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SIZE OF APICAL CONSTRICTION IN DIFFERENT TYPES OF PERMANENT TEETH [PDF]
Journal of IMABBackground: The final size of the apical root canal preparation has been a contraversion issue for a long time. The enlargement of the apical portion of the root canal may severely affect endodontic prognosis.
Evgeni Stanev, Sevda Yantcheva
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Apical constriction is necessary for crypt formation in small intestinal organoids
Developmental Biology, 2019 Small intestinal organoids have become an important tool to study crypt homeostasis, cell fate dynamics and tissue biomechanics. Yet, the mechanisms that drive the budding of crypts from the smooth organoid epithelium remain incompletely understood. Locally enhanced proliferation has been suggested to induce tissue buckling and crypt initiation.
Jeroen van Zon, Sander Tans
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Endocytosis Is Required for Efficient Apical Constriction during Xenopus Gastrulation [PDF]
Current Biology, 2010 Coordinated apical constriction (AC) in epithelial sheets drives tissue invagination [1, 2] and is required for diverse morphogenetic movements such as gastrulation [3], neurulation [4, 5], and organogenesis [6]. We showed previously that actomyosin contractility drives AC in Xenopus laevis bottle cells [7]; however, it remained unclear whether it does
Lee, Jen-Yi, Harland, Richard M.
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Integrins Regulate Apical Constriction via Microtubule Stabilization in the Drosophila Eye Disc Epithelium [PDF]
Cell Reports, 2014 During morphogenesis, extracellular signals trigger actomyosin contractility in subpopulations of cells to coordinate changes in cell shape. To illuminate the link between signaling-mediated tissue patterning and cytoskeletal remodeling, we study the ...
Vilaiwan M. Fernandes +3 more
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A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction [PDF]
EMBO Journal, 2021 Kazuhiro Aoki +2 more
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aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium
Current Biology, 2022 Nicolas Loyer +2 more
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