Results 161 to 170 of about 9,527 (222)

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Apigenin and Metabolic Effects

Önemli bir bitki içeriği olan flavonoidler, yüzyılı aşkındır bilinmekte ve birçok klinik deneysel çalışmada ilgi çeken bileşiklerin başında gelmektedir. Flavonoidler altı alt sınıfa ayrılmaktadır. Apigenin bu alt sınıflardan flavonlar sınıfına dahildir.
Tıraş, Sena, Ercan, Nazlı, Sel, Tevhide   +2 more
openaire   +1 more source

Liquid Chromatography‐Electrospray Ionization‐Tandem Mass Spectrometry Profiling, Antioxidant, Antibacterial, and Antidiabetic Properties of Fagonia cretica L.: Insights From In Vitro and In Silico Approaches

ChemistryOpen, Volume 15, Issue 6, June 2026.
Fagonia cretica L.: Phytochemical investigation and exploration of bioactivity through in vitro and in silico approaches. This study provides an integrative evaluation of the aqueous extract of Fagonia cretica L., a species long employed in traditional medicine but insufficiently characterized through systematic experimental and computational ...
Neghmouche Nacer Salah, Elhafnaoui Lanez, Mohammed Larbi Benamor, Ouafa Zouari Ahmed, Yahia Bekkar, Moussa Senigra, Lazhar Bechki, Stefania Garzoli, Touhami Lanez   +8 more
wiley   +1 more source

High Value‐Added Secondary Raw Material From Winemaking Waste Bentonite to Design Antioxidant Pectin‐Based Mucoadhesive Buccal Films

ChemistryOpen, Volume 15, Issue 6, June 2026.
Hyaluronic acid and/or pectin (crosslinked by calcium lactate) allowed the development of Bentophen200 extract‐loaded buccal films. Given i) the antioxidant power of the polyphenols‐rich extract optimized via multiple maceration of waste bentonite and ii) the flexibility, mucoadhesivity, and suitability of the films for oromucosal application, they can
Giulia Di Prima, Cecilia La Mantia, Viviana De Caro   +2 more
wiley   +1 more source

Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1

Naringenin, an initial synthesized flavanone in various plant species, is further utilized for production of many biologically active flavonoids, e.g., apigenin, eriodictyol, and genistein, by various plant enzymes including cytochrome P450s (P450s or ...
Tsutomu Shimada (1655737), F. Peter Guengerich (272072), Donghak Kim (1337931), Haruna Nagayoshi (1527844), Vitchan Kim (4803177), Hiroshi Yamazaki (78272), Norie Murayama (220718), Shigeo Takenaka (1655734)   +7 more
core   +1 more source

Evaluation of the Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibitory Potential of Salvia heldreichiana Within the Framework of Molecular Docking and CAVER Tunnel Analysis

ChemistryOpen, Volume 15, Issue 6, June 2026.
Methanolic extract of Salvia heldreichiana is characterized by HPLC and GC–MS analyses and evaluated for antioxidant and anti‐Alzheimer activities. Major phenolic compounds are identified, while molecular docking analysis supports the interaction of bioactive constituents with target enzymes, highlighting the therapeutic potential of S.
Erdi Can Aytar, Esin Çolak, Kaan Bedirhan Kahveci, Abidin Gümrükçüoğlu, Süleyman Doğu, Betül Aydın   +5 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley   +1 more source

Lupin (Lupinus angustifolius) as a Protein‐Rich Emerging Crop Adapted to Uruguay: Nutritional and Functional Potential

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Characterization of Lupinus angustifolius cultivated in Uruguay. The figure summarizes the experimental workflow applied to six Lupinus angustifolius samples cultivated in Uruguay. After sample preparation, different analytical approaches were performed: Proximate composition determination of moisture, ash, crude protein, and crude fat by standard AOAC
Matías Rodríguez‐Elhordoy, Jessica Báez, Victoria Olt, Adriana Maite Fernández‐Fernández, Natalia Martínez, Bruno Irigaray, Javier Silva, Mariela Pistón, Daniel Vázquez, Alejandra Medrano   +9 more
wiley   +1 more source

Cladostephus spongiosum as a Novel Protein Source: Bioactive, Techno‐Functional, and Physicochemical Properties

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT Recently, the food industry has been searching for alternative proteins, and macroalgaeare one of the novel protein sources. This study aimed to determine the optimum conditions for ultrasound‐ and enzyme‐assisted protein extraction from Cladostephus spongiosum (CS).
Aysun Yücetepe, Elif Feyza Aydar, Eda Şensu, Zehra Mertdinç, Aslı Can Karaça, Emine Şükran Okudan, Beraat Özçelik   +6 more
wiley   +1 more source