Results 141 to 150 of about 39,255 (266)

Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons

, 2004
Using the patch-clamp technique, we studied the modulation of ionotropic g-aminobutyric acid (GABA) and glutamate neurotransmissionby apigenin, a flavonoid with sedative and antidepressant activity.
M. C. de Vuono, BARALDI, Mario, LOSI, Gabriele, PUJA, Giulia, GARZON, Giorgio   +4 more
core   +1 more source

Artichoke Polyphenols Rich in 1,4‐Dicaffeoylquinic Acid Regulate Lipid Metabolism via the PPAR and AMPK Pathways to Alleviate Hepatic Lipid Accumulation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Artichoke bract polyphenols, particularly from inner bracts, are rich in 1,4‐dicaffeoylquinic acid and chlorogenic acid. In oleic acid‐induced HepG2 cells, these polyphenols activate AMPK and modulate PPARγ signaling, reducing lipid accumulation. These findings highlight the potential of artichoke bracts, including agricultural waste outer bracts, as ...
Wenyang Tao, Chenchen Yang, Quanqin Tan, Wanyi Zhou, Jianrong Xing, Jingrui Li, Mengfan Luo, Ying Yang   +7 more
wiley   +1 more source

Exploring the Cosmeceutical Potential of Six Malaysian Indigenous Tropical Fruit Trees: Radical Scavenging, Anti‐Tyrosinase, and Photoprotective Activities Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
B. macrophylla leaf ethyl acetate fractionated extract exhibits the highest TPC, very strong radical‐scavenging activities, and the highest SPF value of 28.64 ± 0.51. LC‐MS analysis identifies m‐trigallic acid, cis‐coutaric acid, and ellagic acid, which may contribute to its bioactivities. The present work highlights B.
Wei Lee Chong, Zhi Ning Teoh, Nurul Ainanajwa Ramli, Sugumaran Manickam, Siew Huah Lim, Chun Hoe Tan, Kae Shin Sim, Hazwani Mat Saad   +7 more
wiley   +1 more source

Apigenin 7-glucoside and its 2′′- and 6′′-acetates from ligulate flowers of Matricaria chamomilla

, 1980
Dried ligulate flowers of Matricaria chamomilla contain 7-9% glucosides of apigenin and 0.3-0.5% free apigenin. Glucosides were identified as apigenin 7-glucoside and a 1:3 mixture of the 2′′- and 6′′-acetates, as determined by 13C NMR ...
C. Redaelli, E.Santaniello, L. Formentini, Enzo Santaniello, Claudio Redaelli, Lina Formentini   +5 more
core   +1 more source

Cytotoxicity effect of apigenin in nasal fibroblasts.

, 2018
The cytotoxicity test was performed using the IncuCyte® real-time detection system. (A) Structure of apigenin. (B) Nasal fibroblasts were treated with apigenin for 72 hours. Fibroblast viability was calculated by IncuCyte® software.
Hwee-Jin Kim (5702819), Joo-Hoo Park (5702822), Hyun-Woo Yang (5702816), Jae-Min Shin (5756), Heung-Man Lee (659221)   +4 more
core   +1 more source

Component Analysis Based on UHPLC‐Q‐Exactive‐Orbitrap/MS and Immune Regulatory Activity Assessment by an LPS‐Stimulated Macrophages Model of Sacha Inchi Shell (Plukenetia volubilis Linneo) Extract

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The extract of SISE was characterized by LC‐MS, and 44 constituents were identified. Immune function evaluation confirmed that SISWE has a bidirectional immune regulation effect. Further mechanistic studies revealed that SISWE alleviates inflammatory response via suppressing NF‐KB and MAPK signaling pathways.
Min Wang, Yin‐hong Xiang, Hui Li, Qin‐yi Li, Fan Ou‐Yang, Mei Liu, Yao He, Jing Wen, Mei‐qin Huang, Hui‐feng Sun, Zhi‐Gang Wang, Ning Zhang, Jian‐xin Liu   +12 more
wiley   +1 more source

Phytochemical Profiling, Molecular Docking Study, and Gastroprotective Effect of Matricaria chamomilla L. Aqueous Extract in Ethanol‐Induced Gastric Ulcer in Mice

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Matricaria chamomilla L. infusion is not fully documented for its gastroprotective potential despite its rich phenolic content. The relevant combination between the phytochemical profiling of chamomile aqueous extract, multi‐target molecular docking and in vivo approach reveal its gastro mucosal protection achieving 99% in mice through simultaneous ...
Meroua Bouhadjar, Dalila Naimi, Mouna Cheriet, Lillian Barros, Tiane C. Finimundy, Haroun Fadlaoui, Dounia Djabali   +6 more
wiley   +1 more source

Phytochemical Characterization and Biological Activity of Stachys pinardii Extracts

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Ultrasound‐assisted methanol and aqueous extracts of Stachys pinardii are comparatively evaluated for phytochemical composition and biological activities. Solvent polarity markedly influences phenolic profiles and bioactivity. Although the methanolic extract contains higher total phenolics, the aqueous extract exhibits superior antioxidant and enzyme ...
Zeyneb Karakus, Cengiz Sarikurkcu, Arzuhan Sihoglu   +2 more
wiley   +1 more source

Phytochemical Investigation of Stachys hissarica: Antioxidant Activity, Flavonoid Characterization, and In Silico Analysis

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Stachys hissarica demonstrates remarkable antioxidant potential, driven by a rich profile of 35 annotated polyphenolic metabolites within its aqueous methanolic extract. Hydrophilic phenolics exhibit superior radical‐scavenging activity comparable to ascorbic acid. Integrated computational simulations reveal favorable oral bioavailability, low toxicity,
Elbek A. Mukhammadiev, Michal Šoral, Francesco Cacciola, Katia Arena, Chao Liu, Mengqi Zhang, Ruirui Zhang, Doniyor R. Siddikov, Sobirdjan A. Sasmakov, Nilufar Z. Mamadalieva   +9 more
wiley   +1 more source

Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Polyphenol‐rich plant extracts provide natural immunomodulatory protection for oral health through complementary antioxidant, antibacterial, and anti‐inflammatory actions. Their potential to reduce harmful microbial activity and inflammation highlights the promise of dietary polyphenols as a natural strategy for maintaining oral health and preventing ...
Deepa Subramanian, Divya Krishnamoorthi, Gowtham Kannan, Benedict Mathews Paul   +3 more
wiley   +1 more source