Results 141 to 150 of about 9,527 (222)

Apigenin suppresses cancer cell growth through ERbeta

, 2009
Two flavonoids, genistein and apigenin, have been implicated as chemopreventive agents against prostate and breast cancers. However, the mechanisms behind their respective cancer-protective effects may vary significantly.
Mak, Paul, Harwood, Charlotte, Leung, Yuet-Kin, Tang, Wan-Yee, Ho, Shuk-Mei   +4 more
core  

The Antiproliferative and Apoptotic Effects of Apigenin on Glioblastoma Cells

, 2017
OBJECTIVES: Glioblastoma (GBM) is highly proliferative, infiltrative, malignant and the most deadly form of brain tumour. The epidermal growth factor receptor (EGFR) is overexpressed, amplified and mutated in GBM and has been shown to play key and ...
Stump, Trevor, Rebecca J Gryka, Trevor A Stump, Santee, Brittany, Huseman, Eric, Williams, Lauren P., Gryka, Rebecca J., Heinze, Chelsae, Amos, Samson, Samson Amos, Brittany N Santee, Denise S Simpson, Chelsae E Heinze, Lauren P Williams, Rachel A Kunze, Kunze, Rachel, Simpson, Denise, Eric D Huseman   +17 more
core   +1 more source

Nutritional Composition, Therapeutic Benefits, and Functional Food Potential of Coleus amboinicus: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Coleus amboinicus is a nutrient‐rich herb containing vitamins (A‐, C‐, B‐complex), minerals (Ca, Mg, Fe, K), dietary fiber, and potent bioactives such as rosmarinic acid, quercetin, thymol, and carvacrol. These compounds contribute to antioxidant, anti‐inflammatory, antimicrobial, prebiotic, and cardioprotective benefits.
Shani Upadhyay, Rakesh Verma, Shikha Gupta   +2 more
wiley   +1 more source

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source

Isolation of apigenin from Antirrhinum majas

, 2015
Many adults have been exposed to Herpes Simplex Virus Type 1 (HSV-­‐1), which manifests as a painful cold sore. Currently, Acyclovir is the most commonly used drug to reduce the number and severity of HSV-­‐1 outbreaks.
Allen, Shannon
core  

Potential of Aeginetia indica for Alzheimer's Disease Management: In Vitro, In Vivo, and Computational Insights

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
MeOH extract of Aeginetia indica (AİME); chromatographic study: LCMS/MS and GCMS; in vitro assays: AChE assays → ↓ AChE level, ↓ inflammation level and antioxidant assays → ROS; in vivo anti‐inflammatory study: ↓ inflammation level; molecular docking → molecular dynamics simulations: acacetin and acteoside.
Marjanur Rahman Bhuiyan, Md. Sharif Reza, Sadikur Rahman Shuvo, Mustafa Abdullah Yilmaz, Syed Mumtahin Mannan Siam, Md. Shadman Sakib, Oguz Cakir, Md. Nazmul Islam Durjoy, Abbas Tarhan, Nuraniye Eruygur, A. F. M. Shahid Ud Daula   +10 more
wiley   +1 more source

Pharmacology and mechanisms of apigenin in preventing osteoporosis

Frontiers in Pharmacology
Osteoporosis (OP) stands as the most prevalent systemic skeletal condition associated with aging. The current clinical management of OP predominantly depends on anti-resorptive and anabolic agents. Nevertheless, prolonged use of some of these medications has been observed to reduce efficacy and elevate adverse effects. Given the necessity for sustained
Sun Lin, Wang Yincang, Du Jiazhe, Xu Xilin, Xiaofeng Zhang   +4 more
openaire   +3 more sources

Antihyperuricemic Effect of Hawthorn Flavonoid Vitexin: LC–MS Analysis, Network Pharmacology, and In Vivo Verification of Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
UPLC‐MS/MS analysis of hawthorn flavonoids combined with network pharmacology, molecular docking, and molecular dynamics studies predicted vitexin as a key compound acting on the PPARγ/ABCG2 pathway. In a hyperuricemic mouse model, vitexin effectively lowered serum uric acid by enhancing renal and intestinal urate excretion, inhibiting urate production,
Shu‐Yu Wu, Kai‐Wen Kang, Dan‐Yu Huang, Shu‐Ying Li, Hao Zheng, Ri‐Hui Wu, Hui‐Qing Lv, Wan‐Bin Song, Jing Chen, Cheng‐Ping Wen, Li‐She Gan, Xiao Yuan   +11 more
wiley   +1 more source

Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao, Xiao‐li Dong, Rui‐ting Li, Qu‐huan Ma, Xiao‐feng Shi   +4 more
wiley   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source