Results 41 to 50 of about 51,943 (224)

Efficient Synthesis of Apigenin

Journal of Chemical Research, 2013
An efficient synthesis of apigenin using 1,3,5-trimethoxybenzene and anisaldehyde as starting materials is described, involving Friedel–Crafts acylation, selective demethylation, cyclisation, and demethylation. This transformation features a new method for the deprotection of methyl ethers. The overall yields reached approximately 55%.
Ji Zhang, Man Liu, Wei Cui, Jian Yang, Xia-li Liao   +4 more
openaire   +1 more source

Development of a Novel Apigenin Dosage form as a Substitute for the Modern Triple Antithrombotic Regimen

Molecules, 2023
The simultaneous administration of three antiplatelet agents has been proposed as an efficient strategy for the secondary prevention of atherothrombotic events and is included in the European guidelines. However, this strategy presented an increased risk
Antonios D. Tsiailanis, Constantinos C. Tellis, Paraskevi Papakyriakopoulou, Androniki D. Kostagianni, Vasileios Gkalpinos, Christos M. Chatzigiannis, Nikolaos Kostomitsopoulos, Georgia Valsami, Alexandros D. Tselepis, Andreas G. Tzakos   +9 more
doaj   +1 more source

Camomile autofermentation in polyethylene glycol/dextran two-phase system [PDF]

, 2008
The objective of this study was the investigation of the extractive bioconversion of apigenin-7-O-β-glucoside in camomile ligulate flowers into apigenin by autofermentation in polyethylene glycol 6000/dextran 200000 two-phase system.
Antov Mirjana G., Atanacković Milica T., Cvejić Jelena H., Ilić Sanja M., Zeković Zoran P., Đaković Sanja D.   +5 more
core   +1 more source

Total Synthesis of Apigenin

Journal of Chemical Research, 2012
An efficient method for the synthesis of apigenin (4’,5,7-trihydroxyflavone, a traditional medicine) from phloroglucinol and anisaldehyde has been developed. This transformation features a green method for hydroxyl protection as methyl ethers and a different way for cyclisation using iodine in DMSO. The overall yield of 40% is satisfactory.
Jin Wang, Rong-Guang Zhou, Ting Wu, Tao Yang, Qi-Xue Qin, Ii Li, Bo Yang, Jian Yang   +7 more
openaire   +1 more source

Apigenin Provides Structural Protection to Human Fibrinogen against Nitrosative Stress: Biochemical and Molecular Insights

Biomolecules
Background: Peroxynitrite (ONOO−) is an oxidant linked with several human pathologies. Apigenin, a natural flavonoid known for its health benefits, remains unexplored in relation to ONOO− effects.
Aisha Farhana, Abdullah Alsrhani, Yusuf Saleem Khan, Mohammad Salahuddin, Mohammed Ubaidullah Sayeed, Zafar Rasheed   +5 more
doaj   +1 more source

Apigenin directly interacts with and inhibits topoisomerase 1 to upregulate CD26/DPP4 on colorectal carcinoma cells

Frontiers in Pharmacology, 2022
Introduction: CD26/dipeptidyl peptidase IV (DPP4) is a cell-surface glycoprotein present on most epithelial cells that modulates the local response to external signals. We have previously shown that the dietary flavone apigenin (4′,5,7-trihydroxyflavone)
Julia E. Fux, Émilie C. Lefort, Praveen P. N. Rao, Jonathan Blay, Jonathan Blay   +4 more
doaj   +1 more source

Three-Dimensional Printing of an Apigenin-Loaded Mucoadhesive Film for Tailored Therapy to Oral Leukoplakia and the Chemopreventive Effect on a Rat Model of Oral Carcinogenesis

Pharmaceutics, 2022
Oral leukoplakia, which presents as white lesions in the oral cavity, including on the tongue, is precancerous in nature. Conservative treatment is preferable, since surgical removal can markedly reduce the patient’s quality of life. In the present study,
Hiroyuki Takashima, Tatsuaki Tagami, Shinichiro Kato, Heeju Pae, Tetsuya Ozeki, Yasuyuki Shibuya   +5 more
doaj   +1 more source

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage

Advanced Science, EarlyView.
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su, Sisheng Zhang, Lidi Liang, Haiyi Bai, Mei Bai, Hanjun He, Yayu Wang, Huan Liu, Xiangxiu Liang, Yu Sun, Hong Wu   +10 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model

Molecules, 2013
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles in the brain.
Lu Zhang, Jian-Fei Li, Jun-Li Wang, Xiao-Xu Li, Rui Liu, Le Zhao   +5 more
doaj   +1 more source