Results 61 to 70 of about 9,527 (222)

Valorization of Zingiber officinale Roscoe leaf biomass: phytotoxic potential and chemical profiling toward sustainable weed management

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Zingiber officinale Roscoe is widely cultivated as a spice and functional food, generating substantial amounts of aerial biomass that is commonly discarded after harvest. Within a circular‐economy framework, this study investigated the phytotoxic potential of Z.
Sara Vitalini, Orlando Innaurato, Shadab Faramarzi, Alessandro Palmioli, Stefania Garzoli, Valentina Vaglia, Cristina Airoldi, Marcello Iriti   +7 more
wiley   +1 more source

Apigenin: a natural molecule at the intersection of sleep and aging

Frontiers in Nutrition
NAD+, a pivotal coenzyme central to metabolism, exhibits a characteristic decline with age. In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+-consuming glycoprotein CD38.
Daniel J. Kramer, Adiv A. Johnson
doaj   +1 more source

The Pharmacokinetics of Raloxifene and Its Interaction with Apigenin in Rat

Molecules, 2010
Purpose: Raloxifene is a selective estrogen receptor modulator which is structurally similar to tamoxifen. As flavonoids can interact with raloxifene in vitro, we evaluated the in vivo pharmacokinetics of raloxifene in rats when co-administered with ...
Ming Hu, Yan Chen, Xiaobin Jia, Jinyan Wang, Jian Chen   +4 more
doaj   +1 more source

Insights into novel anticancer applications for apigenin [PDF]

Advances in Clinical and Experimental Medicine, 2017
Flavonoids, naturally occuring derivatives of 2-phenyl-benzo-γ-pyrone, are widespread in plants as coloring substances. Apigenin (4',5,7,-trihydroxyflavone (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), molecular formula C₁₅H₁₀O⁵, is a flavonoid present in many fruits and vegetables, primarily in citrus fruits, apples, parsley and celery ...
Adam, Kowalczyk, Agnieszka, Bodalska, Marta, Miranowicz, Katarzyna, Karłowicz-Bodalska   +3 more
openaire   +3 more sources

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2.

PLoS ONE, 2013
Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent. Recombinant human Apo2L/TRAIL has been under clinical trials, whereas various kinds of malignant tumors have resistance to Apo2L ...
Masakatsu Oishi, Yosuke Iizumi, Tomoyuki Taniguchi, Wakana Goi, Tsuneharu Miki, Toshiyuki Sakai   +5 more
doaj   +1 more source

Efficient Synthesis of Apigenin

Journal of Chemical Research, 2013
An efficient synthesis of apigenin using 1,3,5-trimethoxybenzene and anisaldehyde as starting materials is described, involving Friedel–Crafts acylation, selective demethylation, cyclisation, and demethylation. This transformation features a new method for the deprotection of methyl ethers. The overall yields reached approximately 55%.
Ji Zhang, Man Liu, Wei Cui, Jian Yang, Xia-li Liao   +4 more
openaire   +1 more source

Chemical structure and stability of apigenin.

, 2014
(A) 4′, 5, 7-trihydroxyflavone (B) Apigenin stability was determined at 37°C by incubating 20 µM apigenin with or without human prostate cancer PC-3 cells for up to 96 h. The concentration of apigenin at each time point was measured using UV-HPLC. Points±
Rajnee Kanwal (533137), Haripaul Sharma (106050), Natarajan Bhaskaran (293150), Sanjay Gupta (106066)   +3 more
core   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Cognitive deficit is a common problem in epilepsy. A major concern emergent from the use of antiepileptic drugs includes their side effects on learning and memory.
Paria Hashemi, Javad Fahanik Babaei, Somayeh Vazifehkhah, Farnaz Nikbakht   +3 more
doaj   +1 more source