Results 81 to 90 of about 39,255 (266)

Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems

Scientific Reports
This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) to solve the limited oral bioavailability problem of apigenin, a bioactive flavonoid.
Vilasinee Hirunpanich Sato, Hitoshi Sato, Manaw Sangfuang, Jannarin Nontakham, Varaporn Buraphacheep Junyaprasert, Veerawat Teeranachaideekul, Boontida Morakul   +6 more
doaj   +1 more source

Recent insights into the biological functions of apigenin

EXCLI journal, 2020
EXCLI Journal;Vol.
Kim, Jae Kwang, Park, Sang Un
openaire   +3 more sources

Drug Delivery Approaches for Apigenin: A Review

, 2015
Apigenin is a naturally occurring plant flavone with prominent antioxidant and antiinflammatory properties. Although apigenin has the potential to be a promising molecule also for cancer treatment, its delivery to the body requires suitable dosage form ...
Balogh, E., Zariwala, M., Papay, Z.E., Antal, I., Somavarapu, S.   +4 more
core  

Apigenin as an anticancer agent

, 2023
Apigenin is an edible plant-derived flavonoid that has been reported as an anticancer agent in several experimental and biological studies. It exhibits cell growth arrest and apoptosis in different types of tumors such as breast, lung, liver, skin, blood,
M Atif (13428363), T Batool Qaisarani (13510912), M Martorell (13327407), T Aslam Gondal (13498408), M Hanif Mughal (13510915), M Shahbaz (7797335), B Salehi (13510918), M Imran (12678580), Javad Sharifi-Rad (11793598)   +8 more
core  

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Apigenin supplementation substantially improves rooster sperm freezability and post-thaw function

Scientific Reports
This pioneering research investigated apigenin potential to augment rooster sperm cryosurvival in an extender model. Apigenin is a natural antioxidant flavonoid showing promise for improved post-thaw sperm function.
Abouzar Najafi, Hossein Mohammadi, Seyed Davood Sharifi, Amin Rahimi   +3 more
doaj   +1 more source

Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation

Food & Nutrition Research, 2016
Background: Type I interferons (IFN-α/β) have broad and potent immunoregulatory and antiproliferative activities. However, it is still known whether the dietary flavonoids exhibit their antiviral and anticancer properties by modulating the function of ...
Sheng Li, Li-juan Yang, Ping Wang, Yu-jiao He, Jun-mei Huang, Han-wei Liu, Xiao-fei Shen, Fei Wang   +7 more
doaj   +1 more source

Degradation of Her2/Neu by Apigenin Induces Apoptosis through Cytochrome C Release and Caspase-3 Activation in Her2/Neu-Overexpressing Breast Cancer Cells

, 2008
We have shown that exposure of the HER2/neu-overexpressing breast cancer cells to apigenin resulted in induction of apoptosis by depleting HER2/neu protein and, in turn, suppressing the signaling of the HER2/HER3-PI3K/Akt pathway.
魏宗德;高銘欽;林仁混, WAY, TZONG-DER;KAO, MING-CHING;LIN, JEN-KUN   +1 more
core  

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer

, 2017
Xin Jin, Qing Yang, Youwen Zhang Department of Hospital Pharmacy, Suqian Branch Jiangsu Province Hospital, Suzhilu, Suqian, People’s Republic of China Abstract: To develop an alternative treatment for lung cancer, a combination of two potent ...
Jin X, Zhang Y, Yang Q
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