Results 41 to 50 of about 114,772,772 (250)

Apo-12′-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-Activated Receptor γ Activation

, 2018
Apo-lycopenals, lycopene metabolites produced by an initial cleavage by β,β-carotene-9′,10′-oxygenase, exhibit diverse biologically active effects.
Shinsuke Mohri (4763235), Hiroyuki Suganuma (759727), Koichi Aizawa, Teruo Kawada (184343), Tsuyoshi Goto (184310), Shingo Takahashi, Naoko Waki, Takeshi Ara (20446), Tsuyoshi Goto, Teruo Kawada, Shingo Takahashi (692534), Haruya Takahashi (184316), Koichi Aizawa (692535), Takeshi Ara, Haruya Takahashi, Hiroyuki Suganuma, Shinsuke Mohri, Naoko Waki (4763238)   +17 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a]

Journal of Lipid Research, 2000
In this study, we created LDL receptor (LDLr) defective (WHHL) transgenic rabbits expressing human apo[a] to examine whether LDLr mediates the Lp[a] clearance from the plasma.
Jianglin Fan, Mireille Challah, Hiroaki Shimoyamada, Masashi Shiomi, Santica Marcovina, Teruo Watanabe   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Apo-Scabin MD trajectories and EDA.

, 2018
(a) RMDS time-course of 10,000 interposed configurations of the Cα-atoms of apo-Scabin from three 100 ns MD simulations, colored by trajectory as Runa in blue, Runb in green, and Runc in red.
A. Rod Merrill (235587), Bronwyn Lyons (4967011), Miguel R. Lugo (685917), Cristina Lento (4259488), Derek J. Wilson (701828)   +4 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Metabolic heterogeneity of apolipoprotein B in the rat

Journal of Lipid Research, 1981
Triglyceride-rich lipoprotein apoprotein catabolism was studied in rats from 5 to 60 min after intravenous injection of 125I-labeled lipoproteins. The plasma and liver labeled apoprotein content was analyzed by gel filtration column chromatography using ...
C E Sparks, J B Marsh
doaj   +1 more source

Evaluation of Lipid Profile and Apolipoproteins in Essential Hypertensive Patients [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Essential hypertension is one of the most common diseases of the Indian population contributing greatly to the morbidity, mortality and economic burden.
Parsuram Nayak, Suchismita Panda, Pravat Kumar Thatoi, Roma Rattan, Srikrushna Mohapatra, Pramila Kumari Mishra   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source