Results 141 to 150 of about 8,460 (160)

APOBEC restriction goes nuclear

Nature Microbiology, 2018
APOBEC3 restriction, known to inhibit retroviruses by interfering with genome replication and hypermutating viral DNA, targets the γ-herpesvirus Epstein–Barr virus and is antagonized by the viral BORF2 protein.
Malim, Michael H., Pollpeter, Darja
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Retroviral restriction by APOBEC proteins

Nature Reviews Immunology, 2004
A powerful mechanism of vertebrate innate immunity has been discovered in the past year, in which APOBEC proteins inhibit retroviruses by deaminating cytosine residues in nascent retroviral cDNA. To thwart this cellular defence, HIV encodes Vif, a small protein that mediates APOBEC degradation.
Reuben S, Harris, Mark T, Liddament
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APOBEC: From mutator to editor

Journal of Genetics and Genomics, 2017
APOBECs (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) are a family of cytidine deaminases that prefer single-stranded nucleic acids as substrates. Besides their physiological functions, APOBEC family members have been found to cause hypermutations of cancer genomes, which could be correlated with cancer development and poor ...
Bei Yang, Xiaosa Li, Liqun Lei, Jia Chen
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Genetic modifiers of APOBEC-induced mutagenesis

2023
AbstractThe cytidine deaminases APOBEC3A and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we utilized a screen to identify 61 gene deletions that increase A3B-induced mutations in yeast.
Tony M, Mertz, Elizabeth, Rice-Reynolds, Ly, Nguyen, Anna, Wood, Nicholas, Bray, Debra, Mitchell, Kirill, Lobachev, Steven A, Roberts   +7 more
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APOBEC-Mediated Editing of Viral RNA

Science, 2004
Retroviral DNA can be subjected to cytosine-to-uracil editing through the action of members of the APOBEC family of cytidine deaminases. Here we demonstrate that APOBEC-mediated cytidine deamination of human immunodeficiency virus (HIV) virion RNA can also occur.
Bishop, K N, Holmes, R K, Sheehy, A M, Malim, M H   +3 more
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APOBEC mediated mutagenesis drives genomic heterogeneity in endometriosis

Journal of Human Genetics, 2022
Endometriosis is a benign gynecologic condition, acting as a precursor of certain histological subtypes of ovarian cancers. The epithelial cells of endometriotic tissues and normal uterine endometrium accumulated somatic mutations in cancer-associated genes such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and ...
Sundaramoorthy Revathidevi, Hirofumi Nakaoka, Kazuaki Suda, Naoko Fujito, Arasambattu Kannan Munirajan, Kosuke Yoshihara, Takayuki Enomoto, Ituro Inoue   +7 more
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Modulating APOBEC expression enhances DNA vaccine immunogenicity

Immunology & Cell Biology, 2015
DNA vaccines have failed to induce satisfactory immune responses in humans. Several mechanisms of double‐stranded DNA (dsDNA) sensing have been described, and modulate DNA vaccine immunogenicity at many levels. We hypothesized that the immunogenicity of DNA vaccines in humans is suppressed by APOBEC (apolipoprotein B (APOB) mRNA‐editing, catalytic ...
Rafael Ribeiro, Almeida, Rui André Saraiva, Raposo, Fernanda Caroline, Coirada, Jamile Ramos, da Silva, Luís Carlos, de Souza Ferreira, Jorge, Kalil, Douglas F, Nixon, Edecio, Cunha-Neto   +7 more
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Biochemical assays for AID/APOBECs and the identification of AID/APOBEC inhibitors

Activation-induced cytidine deaminase (AID) and apolipoprotein B-mRNA editing catalytic polypeptide 3 (APOBEC3 or A3) proteins belong to the AID/APOBEC family of cytidine deaminases. While AID mediates somatic hypermutation and class-switch recombination in adaptive immunity, A3s restrict viruses and retroelements by hypermutation.
Priyanka, Govindarajan, Ying, Zeng, Mani, Larijani   +2 more
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Apobec-1 and apolipoprotein B mRNA editing

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
Apolipoprotein (apo)B mRNA editing is a novel mechanism for the post-transcriptional regulation of gene expression in mammals. It consists of a C-->U conversion of the first base of the codon CAA, encoding glutamine-2153, to UAA, an in-frame stop codon, in apoB mRNA.
L, Chan, B H, Chang, M, Nakamuta, W H, Li, L C, Smith   +4 more
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Enhancing immunity to HIV through APOBEC

Nature Biotechnology, 2008
A small molecule that interferes with HIV Vif promotes the antiviral activity of the human protein APOBEC3G.
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