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The crystal structure of APOBEC-2 and implications for APOBEC enzymes
2015APOBEC-2 (Apo2) belongs to the Apolioprotein B (APOB) mRNA-editing enzyme catalytic polypeptide (APOBEC) family of cytidine deaminases that modify genes by deaminating cytosines in mRNA coding sequences and cytidines in ssDNA (Franca et al., 2006). APOBEC deaminases have remarkably diverse functions comprising antibody maturation, inactivation of viral
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APOBEC Family Proteins: Novel Antiviral Innate Immunity
International Journal of Hematology, 2006APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1.
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Targeting APOBECs in cancer: It’s about timing
Cancer CellAPOBEC3 cytidine deaminases have emerged as key drivers of mutagenesis in a wide spectrum of tumor types and are now appreciated to play a causal role in driving tumor evolution and drug resistance. As efforts to develop APOBEC3 inhibitors progress, understanding the timing and consequences of APOBEC3-mediated mutagenesis in distinct clinical contexts ...
Aaron N, Hata, Mani, Larijani
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Fluorescent shift assay for APOBEC-mediated RNA editing
Cytidine (C) to Uridine (U) RNA editing is a post-transcriptional modification that is involved in diverse biological processes. The APOBEC deaminase family acts in various cellular processes mostly through inducing C-to-U mutation in single-stranded RNA (or DNA).Shanshan, Wang +2 more
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Biochemical studies of APOBEC protein family
2016APOBEC3F (A3F) is a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) family of proteins that can deaminate cytosine (C) to uracil (U) on nucleic acids. A3F is one of the four APOBEC members with two Zn-coordinated homologous cytosine deaminase domains (CDs), with the others being A3B, A3DE and A3G. ? Here we report
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[Hepatitis B virus and APOBEC family].
Seikagaku. The Journal of Japanese Biochemical Society, 2018Masamichi, Muramatsu +2 more
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[Interplay between HIV-1 and APOBEC].
Seikagaku. The Journal of Japanese Biochemical Society, 2018Kei, Sato, Yoshio, Koyanagi
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Genetics: APOBEC-a double-edged sword.
Nature reviews. Clinical oncology, 2014openaire +1 more source