Retrotransposons as gene expression regulators [PDF]
, 2017 Retrotranspozoni su pokretni genetički elementi koji se kreću po genomu putem RNA intermedijera. Tri su glavne grupe retrotranspozona; LTR (long terminal repeat) retrotranspozoni, elementi LINE (long interspersed elements) i elementi SINE (short ...
Rimanić, Hana
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136 HIV-1 Nef regulates activity of endoplasmic reticulum chaperone calnexin [PDF]
, 2014 HIV-1 Nef promotes viral replication by downmodulating a number of cell surface transmembrane proteins, such as CD4, MHC-I and MHC-II, which are targeted by Nef to various degradation pathways.
Bukrinsky*, Michael +6 more
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APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution [PDF]
, 2018 The APOBEC mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade.
Bartek, J +8 more
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Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals [PDF]
, 2013 Introduction: Human APOBEC3G/F (hA3G/F) restricts retroviral replication through G-to-A hypermutations, which can generate drug-resistant progenies in vitro. The clinical relevance is still inconclusive.
Akhil C Banerjea +37 more
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APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution
HeliyonSARS-CoV-2 evolves gradually to cause COVID-19 epidemic. One of driving forces of SARS-CoV-2 evolution might be activation of apolipoprotein B mRNA editing catalytic subunit-like protein 3 (APOBEC3) by inflammatory factors.
Jiaying Shen +12 more
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In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein
Bio-Protocol, 2014 Cytidine deaminases are enzymes that catalyze the removal of an amino group from cytidine, forming uridine. APOBEC3 (ApolipoproteinB mRNA editing enzyme, catalytic polypeptide like) proteins are cytidine deaminases that deaminate cytidines in ...
Smita Nair, Smita Nair
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The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators [PDF]
, 2013 The activation of CD4(+) T helper cells is strictly dependent on the presentation of antigenic peptides by MHC class II (MHC-II) molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (class II ...
Abdallah, R. +3 more
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Genomic impact of eukaryotic transposable elements [PDF]
, 2012 © The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Mobile DNA 3 (2012): 19, doi:10.1186/1759-8753-3-19.The third international conference on the genomic
Arkhipova, Irina R. +6 more
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PLoS Pathogens, 2008 Because of evolutionary pressures imposed through episodic colonization by retroviruses, many mammals express factors, such as TRIM5alpha and APOBEC3 proteins, that directly restrict retroviral replication.
David Perez-Caballero +2 more
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No evidence of xenotropic murine leukemia virus-related virus transmission by blood transfusion from infected rhesus macaques [PDF]
, 2012 The discovery of xenotropic murine leukemia virus-related virus (XMRV) in human tissue samples has been shown to be due to virus contamination with a recombinant murine retrovirus.
Galvin, Teresa A +5 more
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