Results 131 to 140 of about 7,631 (195)

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. [PDF]

, 2020
With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in ...
Chen, Qu, Fu, Xuemei, Kim, Jinchul, Liu, Jingfeng, Tang, Qingshuang, Xu, Shuxiang, Xu, Yang   +6 more
core  

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity

Cell Reports, 2015
HIV-1 encodes the accessory protein Vif, which hijacks a host Cullin-RING ubiquitin ligase (CRL) complex as well as the non-canonical cofactor CBFβ, to antagonize APOBEC3 antiviral proteins.
Joshua R. Kane, David J. Stanley, Judd F. Hultquist, Jeffrey R. Johnson, Nicole Mietrach, Jennifer M. Binning, Stefán R. Jónsson, Sarah Barelier, Billy W. Newton, Tasha L. Johnson, Kathleen E. Franks-Skiba, Ming Li, William L. Brown, Hörður I. Gunnarsson, Adalbjorg Adalbjornsdóttir, James S. Fraser, Reuben S. Harris, Valgerður Andrésdóttir, John D. Gross, Nevan J. Krogan   +19 more
doaj   +1 more source

Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction

Journal of Virology
Several APOBEC3 enzymes restrict HIV-1 by deaminating cytosine to form uracil in single-stranded proviral (−)DNA. However, HIV-1 Vif counteracts their activity by inducing their proteasomal degradation.
Amit Gaba, Maria Yousefi, Shreoshri Bhattacharjee, Linda Chelico   +3 more
doaj   +1 more source

APOBEC3 Proteins: From Antiviral Immunity to Oncogenic Drivers in HPV-Positive Cancers

Viruses
The human APOBEC superfamily consists of eleven cytidine deaminase enzymes. Among them, APOBEC3 enzymes play a dual role in antiviral immunity and cancer development. APOBEC3 enzymes, including APOBEC3A (A3A) and APOBEC3B (A3B), induce mutations in viral
Eliza Pizarro Castilha, Rosalba Biondo, Kleber Paiva Trugilo, Giulia Mariane Fortunato, Timothy Robert Fenton, Karen Brajão de Oliveira   +5 more
doaj   +1 more source

Human-likeAPOBEC3gene expression and anti-viral responses following replacement of mouseApobec3with the 7-gene humanAPOBEC3locus

AbstractThe seven human APOBEC3 (hA3) genes encode polynucleotide cytidine deaminases that play vital roles in restricting replication of viruses and retrotransposons. However, off-target A3 deamination of the cellular genome is a major source of somatic mutations in human cancer.
Nerissa K Kirkwood, Haydn M Prosser, Melvyn W Yap, Jane Gibson, Ross Cook, Ian Reddin, Ane Stranger, Emma Howes, Nur Zainal, Manikandan Periyasamy, Silvestro G Conticello, Gareth J. Thomas, James Scott, Kate N Bishop, Simak Ali, Allan Bradley, Tim R Fenton   +16 more
openaire   +1 more source

APOBEC3B expression in 293T viral producer cells drives mutations in chimeric antigen receptors and reduces CAR T cell efficacy

Molecular Therapy: Oncology
Chimeric antigen receptor (CAR) T cells are a clinically approved therapy for blood cancers. To produce clinical-grade CAR T cells, a retroviral or lentiviral vector is used to deliver the CAR and associated genes to patient T cells.
Jack Swanson, Jason Tonne, Thanich Sangsuwannukul, Jill Thompson, Benjamin Kendall, Olivia Liseth, Muriel Metko, Richard Vile   +7 more
doaj   +1 more source

Gene Discovery and Data Sharing in Genome Wide Association Analyses: Lessons Form AIDS Genetic Restriction Genes [PDF]

, 2014
As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative ...
Cherkasov, Nikolay, Dobrynin, Pavel, Geerts, Paul, Hendrickson, Sher L., Hutcheson, Holli, Malov, Sergey, O\u27Brien, Stephen J., Sezgin, Efe, Svitin, Anton, Troyer, Jennifer L.   +9 more
core   +1 more source

Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif [PDF]

, 2013

core   +1 more source

Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells [PDF]

, 2016
Gaël Cristofari, Javier G. Pizarro
core   +1 more source

Dynamics of antiretroviral restriction factor expression in sheep naturally infected with Small ruminant lentivirus (SRLV). [PDF]

Arch Virol
Rodríguez-Murillo C, González-Fernández VD, Castillo-Hernández G, Akbarin MM, Álvarez HR.   +4 more
europepmc   +1 more source