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APOBEC3 Proteins and Porcine Endogenous Retroviruses

Transplantation Proceedings, 2008
Xenotransplantation of porcine cells, tissues, and organs offers a solution to overcome the shortage of human donor materials. In addition to the immunological and physiological barriers, the existence of numerous porcine microorganisms including viruses poses a risk for xenozoonosis.
E, Dörrschuck, C, Münk, R R, Tönjes
openaire   +2 more sources

Multifaceted antiviral actions of APOBEC3 cytidine deaminases

Trends in Immunology, 2006
To defend against external pathogens, metazoan organisms have evolved numerous defenses that generally fall within the innate and adaptive immune responses. Considerable effort continues to focus on developing a vaccine to manipulate the adaptive immune system to protect against or control HIV-1.
Ya-Lin, Chiu, Warner C, Greene
openaire   +2 more sources

APOBEC3 inhibits mouse mammary tumour virus replication in vivo

Nature, 2007
Genomes of all mammals encode apobec3 genes, which are thought to have a function in intrinsic cellular immunity to several viruses including human immunodeficiency virus type 1 (HIV-1). APOBEC3 (A3) proteins are packaged into virions and inhibit retroviral replication in newly infected cells, at least in part by deaminating cytidines on the negative ...
Chioma M, Okeoma   +3 more
openaire   +2 more sources

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