Encapsidation of APOBEC3G into HIV-1 virions involves lipid raft association and does not correlate with APOBEC3G oligomerization [PDF]
Retrovirology, 2009 Abstract Background The cellular cytidine deaminase APOBEC3G (A3G), when incorporated into the human immunodeficiency virus type 1 (HIV-1), renders viral particles non-infectious. We previously observed that mutation of a single cysteine residue of A3G (C100S) inhibited A3G packaging.
Walker Robert C +5 more
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AIDS Research and Therapy, 2012 Introduction Human APOBEC3G is a host defense factor that potently inhibits HIV replication. We hypothesize that HIV-infected children with a genetic variant of APOBEC3G will have a more rapid disease progression.
Bunupuradah Torsak +12 more
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HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G. [PDF]
PLoS Pathogens, 2018 HIV-1 replication normally requires Vif-mediated neutralization of APOBEC3 antiviral enzymes. Viruses lacking Vif succumb to deamination-dependent and -independent restriction processes.
Terumasa Ikeda +5 more
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Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G
Nature Communications, 2022 Interaction between APOBEC3G and RNA is critical for its antiviral function. Here, the authors report four co-crystal structures of rhesus macaque APOBEC3G and RNA, demonstrating unpaired AA and GA dinucleotide motifs are preferentially recognized.
Hanjing Yang +4 more
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APOBEC3G levels predict rates of progression to AIDS [PDF]
Retrovirology, 2007 APOBEC3G (hA3G) is a newly discovered cellular factor of innate immunity that inhibits HIV replication in vitro. Whether hA3G confers protection against HIV in vivo is not known. To investigate the possible anti-HIV activity of hA3G in vivo, we examined hA3G mRNA abundance in primary human cells isolated from either HIV-infected or HIV-uninfected ...
Wu Hulin, Jin Xia, Smith Harold
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Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.
PLoS Pathogens, 2006 APOBEC3G is an antiviral host factor capable of inhibiting the replication of both exogenous and endogenous retroviruses as well as hepatitis B, a DNA virus that replicates through an RNA intermediate.
Michael J Wichroski +2 more
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Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma
Blood Cancer Journal, 2021 Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported.
Srikanth Talluri +8 more
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Restriction of retroviral replication by APOBEC3G/F and TRIM5α [PDF]
Trends in Microbiology, 2008 Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms.
Huthoff, Hendrik, Towers, Greg J.
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Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. [PDF]
PLoS Pathogens, 2012 The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription.
Eric W Refsland +2 more
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Identification of an APOBEC3G Binding Site in Human Immunodeficiency Virus Type 1 Vif and Inhibitors of Vif-APOBEC3G Binding [PDF]
Journal of Virology, 2007 ABSTRACT The APOBEC3 cytidine deaminases are potent antiviral factors that restrict replication of human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif binds APOBEC3G and APOBEC3F and targets these proteins for ubiquitination by forming an E3 ubiquitin ligase with cullin 5 and elongins B and C.
Andrew, Mehle +6 more
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