Results 21 to 30 of about 6,750 (198)
APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study. [PDF]
PLoS ONE, 2013 The interplay between the innate immune system restriction factor APOBEC3G and the HIV protein Vif is a key host-retrovirus interaction. APOBEC3G can counteract HIV infection in at least two ways: by inducing lethal mutations on the viral cDNA; and by ...
Iraj Hosseini, Feilim Mac Gabhann
doaj +2 more sources
APOBEC3G expression and HIV-1 infection in Burkina Faso [PDF]
Journal of Public Health in Africa, 2018 APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of ...
Tegwinde Rebeca Compaore +11 more
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Human APOBEC3G incorporation into murine leukemia virus particles [PDF]
Virology, 2005 The human APOBEC3G protein exhibits broad antiretroviral activity against a variety of retroviruses. It is packaged into viral particles and executes its antiviral function in the target cell.
Barbara S Schnierle
exaly +2 more sources
HIV-1 Vif and APOBEC3G: Multiple roads to one goal [PDF]
Retrovirology, 2004 The viral infectivity factor, Vif, of human immunodeficiency virus type 1, HIV-1, has long been shown to promote viral replication in vivo and to serve a critical function for productive infection of non-permissive cells, like peripheral blood ...
Goncalves Joao, Santa-Marta Mariana
doaj +2 more sources
APOBEC3G encapsidation into HIV-1 virions: which RNA is it? [PDF]
Retrovirology, 2008 APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs.
Khan Mohammad A, Strebel Klaus
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APOBEC3G: an intracellular centurion [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 The intrinsic antiretroviral factor APOBEC3G (A3G) is highly active against HIV-1 and other retroviruses. In different cell types, A3G is expressed in high-molecular-mass (HMM) RNA–protein complexes or low-molecular-mass (LMM) forms displaying different biological activities.
Ya-Lin, Chiu, Warner C, Greene
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Heliyon, 2022 Background: Kidney renal clear cell carcinoma (KIRC) is the most common pathological subtype of renal cell cancer. APOBEC3 activity has been identified in a variety of human cancers.
Ting Peng +9 more
doaj +1 more source
Viruses, 2022 APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV.
Fareeda M. Barzak +10 more
doaj +1 more source
The Roles of APOBEC3G Complexes in the Incorporation of APOBEC3G into HIV-1
PLoS ONE, 2013 The incorporation of human APOBEC3G (hA3G) into HIV is required for exerting its antiviral activity, therefore the mechanism underlying hA3G virion encapsidation has been investigated extensively. hA3G was shown to form low-molecular-mass (LMM) and high-molecular-mass (HMM) complexes.
Jing Ma +12 more
openaire +4 more sources
APOBEC3G Targets Specific Virus Species [PDF]
Journal of Virology, 2004 ABSTRACT Human APOBEC3G (huAPOBEC3G), also known as CEM15, is a broad antiretroviral host factor that deaminates dC to dU in the minus strand DNA of human immunodeficiency virus type 1 (HIV-1), other lentiviruses, and murine leukemia virus (MLV), thereby creating G-to-A hypermutation in the plus strand DNA to inhibit the infectivity of these ...
Masayuki, Kobayashi +5 more
openaire +2 more sources