Results 11 to 20 of about 6,750 (198)
APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication [PDF]
Retrovirology, 2008 Background Although APOBEC3G protein is a potent and innate anti-HIV-1 cellular factor, HIV-1 Vif counteracts the effect of APOBEC3G by promoting its degradation through proteasome-mediated proteolysis.
Li Lin +3 more
doaj +4 more sources
APOBEC3G & HTLV-1: Inhibition without deamination [PDF]
Retrovirology, 2005 APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines.
Strebel Klaus
doaj +5 more sources
Characterization of APOBEC3G binding to 7SL RNA [PDF]
Retrovirology, 2008 Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retroviruses such as human immunodeficiency virus (HIV), hepadnaviruses such as hepatitis B virus (HBV), and with the retrotransposition of endogenous ...
Lakkaraju Asvin +5 more
doaj +7 more sources
Complementary function of the two catalytic domains of APOBEC3G [PDF]
Virology, 2005 The HIV-1 viral accessory protein Vif prevents the encapsidation of the antiviral cellular cytidine deaminases APOBEC3F and APOBEC3G by inducing their proteasomal degradation.
Nathaniel Landau, Renate König
exaly +4 more sources
Radiosensitization to γ-Ray by Functional Inhibition of APOBEC3G [PDF]
International Journal of Molecular Sciences, 2022 The radiosensitization of tumor cells is one of the promising approaches for enhancing radiation damage to cancer cells and limiting radiation effects on normal tissue.
Fujimori, Hiroaki +21 more
core +5 more sources
The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]
PLoS ONE, 2007 The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson +5 more
doaj +5 more sources
Vaccinia virus replication is not affected by APOBEC3 family members [PDF]
Virology Journal, 2006 Background The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd +5 more
doaj +2 more sources
Selective inhibition of Alu retrotransposition by APOBEC3G [PDF]
Gene, 2007 The non-LTR retrotransposon LINE-1 (L1) comprises ∼ 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs ...
Cullen, Bryan R. +3 more
core +3 more sources
Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent [PDF]
Virology, 2009 Cytidine deamination is the primary mechanism by which APOBEC3G restricts HIV-1; however, several studies have reported that APOBEC3G also inhibits virus replication via a mechanism that is independent of deamination.
Edward P Browne, Nathaniel Landau
exaly +2 more sources
APOBEC3G targets human T-cell leukemia virus type 1 [PDF]
Retrovirology, 2005 Background Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cellular protein with a broad antiviral activity.
Imada Kazunori +8 more
doaj +2 more sources