Results 31 to 40 of about 6,750 (198)

Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms. [PDF]

PLoS Pathogens, 2014
The APOBEC3 deoxycytidine deaminase family functions as host restriction factors that can block replication of Vif (virus infectivity factor) deficient HIV-1 virions to differing degrees by deaminating cytosines to uracils in single-stranded (-)HIV-1 DNA.
Anjuman Ara, Robin P Love, Linda Chelico
doaj   +1 more source

The Role of Innate APOBEC3G and Adaptive AID Immune Responses in HLA-HIV/SIV Immunized SHIV Infected Macaques [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Wang, Yufei, Singh Mahavir, Schøller, Jørgen, David Montefiori, Bunnik, Evelien M, Montefiori, D, Vaughan Robert, Mahavir Singh, Jørgen Schøller, Singh, Mahavir, Bergmeier, LA, Whittall, T, Thomas Lehner (171103), Rahman Durdana, Mahavir Singh (70735), Durdana Rahman (171080), Scholler, J, Vaughan, Robert, Rahman, D, Vaughan, R, Singh, M, Whittall Trevor, Bunnik Evelien M., Robert Vaughan, Thomas Lehner, Lesley A. Bergmeier (171089), Rahman, Durdana, Montefiori, David, Yufei Wang (171069), Evelien M. Bunnik (125512), Bergmeier, Lesley A., Whittall, Trevor, Lehner, T, Schøller Jørgen, Lehner Thomas, Hanneke Schuitemaker, Yufei Wang, Bergmeier, Lesley A, Lehner, Thomas, Lesley A Bergmeier, Schuitemaker, Hanneke, Montefiori David, Schuitemaker, H, Schuitemaker Hanneke, Bunnik, Evelien M., Trevor Whittall (171074), Trevor Whittall, Hanneke Schuitemaker (85702), David Montefiori (161606), Wang, Y, Robert Vaughan (5968), Jørgen Schøller (143988), Wang Yufei, Bergmeier Lesley A., Durdana Rahman, Bunnik, EM, Evelien M Bunnik   +56 more
core   +1 more source

APOBEC3G: a double agent in defense [PDF]

Trends in Biochemical Sciences, 2011
APOBEC3G (A3G) is an effective cellular host defense factor under experimental conditions in which a functional form of the HIV-encoded protein Vif cannot be expressed. Wild-type Vif targets A3G for proteasomal degradation and when this happens, any host defense advantage A3G might provide is severely diminished or lost.
openaire   +2 more sources

Hypermutation of an Ancient Human Retrovirus by APOBEC3G [PDF]

Journal of Virology, 2008
ABSTRACT Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome, but all are remnants of ancient retroviral infections and harbor inactivating mutations that render them replication defective. Nevertheless, as viral “fossils,” HERVs may provide insights into ancient retrovirus-host interactions and their evolution.
Lee, Y N, Malim, M H, Bieniasz, P D
openaire   +3 more sources

Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G. [PDF]

PLoS ONE, 2012
The mammalian two-hybrid system MAPPIT allows the detection of protein-protein interactions in intact human cells. We developed a random mutagenesis screening strategy based on MAPPIT to detect mutations that disrupt the interaction of one protein with ...
Isabel Uyttendaele, Delphine Lavens, Dominiek Catteeuw, Irma Lemmens, Celia Bovijn, Jan Tavernier, Frank Peelman   +6 more
doaj   +1 more source

The cellular source for APOBEC3G's incorporation into HIV-1 [PDF]

Retrovirology, 2011
Human APOBEC3G (hA3G) has been identified as a cellular inhibitor of HIV-1 infectivity. Viral incorporation of hA3G is an essential step for its antiviral activity. Although the mechanism underlying hA3G virion encapsidation has been investigated extensively, the cellular source of viral hA3G remains unclear.Previous studies have shown that hA3G forms ...
Guo Fei, Zhou Jinming, Jia Pingping, Liu Zhenlong, Zhang Quan, Xu Jian, Li Xiaoyu, Ma Jing, You Xuefu, Yu Liyan, Zhao Lixun, Jiang Jiandong, Cen Shan   +12 more
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Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells. [PDF]

PLoS Pathogens, 2009
HIV-1 is restricted for infection of primary quiescent T-cells. After viral entry, reverse transcription is initiated but is not completed. Various hypotheses have been proposed for this cellular restriction including insufficient nucleotide pools and ...
Masakazu Kamata, Yoshiko Nagaoka, Irvin S Y Chen   +2 more
doaj   +1 more source

Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells

Retrovirology, 2004
Background The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions. Inhibition of APOBEC3G encapsidation is paralleled by a reduction of its intracellular
Goila-Gaur Ritu, Opi Sandrine, Takeuchi Hiroaki, Khan Mohammad A, Miyagi Eri, Kao Sandra, Strebel Klaus   +6 more
doaj   +1 more source

Functional domain organization of human APOBEC3G

Virology, 2008
Human APOBEC3 proteins exist in two forms containing either a single cytidine deaminase domain (CDA) or two CDAs. Strikingly, the proteins that are capable of effectively inhibiting the infectivity of Vif-deficient HIV-1 (HIV-1DeltaVif), such as APOBEC3G (A3G), contain two CDAs.
Gooch, Barry D., Cullen, Bryan R.
openaire   +2 more sources

Nanoscale Characterization of Interaction of APOBEC3G with RNA

Biochemistry, 2017
The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of the HIV-1 virus in the absence of viral infectivity factor (Vif). The molecular mechanism of A3G antiviral activity is primarily attributed to deamination of single-stranded DNA (ssDNA); however, the nondeamination mechanism also contributes to HIV-1 restriction.
Pan, Yangang, Sun, Zhiqiang, Maiti, Atanu, Kanai, Tapan, Matsuo, Hiroshi, Li, Ming, Harris, Reuben S., Shlyakhtenko, Luda S., Lyubchenko, Yuri L.   +8 more
openaire   +3 more sources