Results 71 to 80 of about 5,264 (176)

Nanoscale Characterization of Interaction of APOBEC3G with RNA

Biochemistry, 2017
The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of the HIV-1 virus in the absence of viral infectivity factor (Vif). The molecular mechanism of A3G antiviral activity is primarily attributed to deamination of single-stranded DNA (ssDNA); however, the nondeamination mechanism also contributes to HIV-1 restriction.
Pan, Yangang, Sun, Zhiqiang, Maiti, Atanu, Kanai, Tapan, Matsuo, Hiroshi, Li, Ming, Harris, Reuben S., Shlyakhtenko, Luda S., Lyubchenko, Yuri L.   +8 more
openaire   +3 more sources

Identification of an APOBEC3G Binding Site in Human Immunodeficiency Virus Type 1 Vif and Inhibitors of Vif-APOBEC3G Binding [PDF]

Journal of Virology, 2007
ABSTRACT The APOBEC3 cytidine deaminases are potent antiviral factors that restrict replication of human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif binds APOBEC3G and APOBEC3F and targets these proteins for ubiquitination by forming an E3 ubiquitin ligase with cullin 5 and elongins B and C.
Andrew, Mehle, Heather, Wilson, Chengsheng, Zhang, Andrew Jay, Brazier, Mark, McPike, Erez, Pery, Dana, Gabuzda   +6 more
openaire   +2 more sources

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

Influenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam, Vinod R. M. T. Balasubramaniam   +1 more
wiley   +1 more source

The cellular source for APOBEC3G's incorporation into HIV-1 [PDF]

Retrovirology, 2011
Human APOBEC3G (hA3G) has been identified as a cellular inhibitor of HIV-1 infectivity. Viral incorporation of hA3G is an essential step for its antiviral activity. Although the mechanism underlying hA3G virion encapsidation has been investigated extensively, the cellular source of viral hA3G remains unclear.Previous studies have shown that hA3G forms ...
Guo Fei, Zhou Jinming, Jia Pingping, Liu Zhenlong, Zhang Quan, Xu Jian, Li Xiaoyu, Ma Jing, You Xuefu, Yu Liyan, Zhao Lixun, Jiang Jiandong, Cen Shan   +12 more
openaire   +3 more sources

Conformational Space Profiling Enhances Generic Molecular Representation for AI‐Powered Ligand‐Based Drug Discovery

Advanced Science, Volume 11, Issue 40, October 28, 2024.
By incorporating the molecular conformational space profile into the contrastive pre‐training, the authors have developed a molecular representation model called GeminiMol, which is trained on a small‐scale molecular dataset but has a relatively strong generalization ability on large‐scale benchmark datasets.
Lin Wang, Shihang Wang, Hao Yang, Shiwei Li, Xinyu Wang, Yongqi Zhou, Siyuan Tian, Lu Liu, Fang Bai   +8 more
wiley   +1 more source

APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies [PDF]

Scientific Reports, 2015
AbstractAPOBEC3G (A3G) protein has antiviral activity against HIV and other pathogenic retroviruses. A3G has two domains: a catalytic C-terminal domain (CTD) that deaminates cytidine and a N-terminal domain (NTD) that binds to ssDNA. Although abundant information exists about the biological activities of A3G protein, the interplay between sequence ...
Shlyakhtenko, Luda S., Dutta, Samrat, Banga, Jaspreet, Li, Ming, Harris, Reuben S., Lyubchenko, Yuri L.   +5 more
openaire   +3 more sources

Vpu and BST2: still not there yet?

Frontiers in Microbiology, 2012
Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV-1 replication and are widely accepted as ‘restriction factors’.
Kei eSato, Peter eGee, Yoshio eKoyanagi, Yoshio eKoyanagi   +3 more
doaj   +1 more source

Unveiling the promise: Exosomes as game‐changers in anti‐infective therapy

Exploration, Volume 4, Issue 5, October 2024.
A comprehensive review to reveal new insights into exosomes’ distinctiveness, the growing availability of new analytical tools that drive the development of next‐generation synthetic systems were presented. Herein, light is shed on exosomes as drug delivery vehicles in anti‐infective therapy.
Vivek P. Chavda, Guanghong Luo, Rajashri Bezbaruah, Tutumoni Kalita, Anupam Sarma, Gitima Deka, Yanhong Duo, Bhrigu Kumar Das, Yesha Shah, Humzah Postwala   +9 more
wiley   +1 more source

HIV vaccination: Navigating the path to a transformative breakthrough—A review of current evidence

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background and Aim Human immunodeficiency virus (HIV) remains a significant global health challenge, with approximately 39 million people living with HIV worldwide as of 2022. Despite progress in antiretroviral therapy, achieving the UNAIDS “95‐95‐95” target to end the HIV epidemic by 2025 faces challenges, particularly in sub‐Saharan Africa ...
Godfred Yawson Scott, Dominic Worku
wiley   +1 more source

Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

Genome Biology, 2019
Background Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon.
Shraddha Sharma, Jianmin Wang, Emad Alqassim, Scott Portwood, Eduardo Cortes Gomez, Orla Maguire, Per H. Basse, Eunice S. Wang, Brahm H. Segal, Bora E. Baysal   +9 more
doaj   +1 more source