Results 81 to 90 of about 6,750 (198)

Contribution of APOBEC3G/F Activity to the Development of Low-Abundance Drug-Resistant HIV-1 variants.

, 2016
Plasma drug-resistant minority HIV-1 variants (DRMV) increase the risk of virological failure to first-line NNRTI antiretroviral therapy (ART). The origin of DRMVs in ART-naive patients, however, remains unclear.
Castro, E., Ceccherini-Silberstein, Francesca, Michalik, Claudia, Furrer, H, D'Arminio Monforte, Antonella, Cozzi-Lepri, A., Paredes, Roger, Geretti, A M, Di Giallonardo, Francesca, Ceccherini-Silberstein, F, Schultze, A, Aitken, S., Cozzi-Lepri, A, Ceccherini-Silberstein, F., Bellecave, P., Metzner, Karin J, Furrer, Hansjakob, Metzner, K.J., Booth, Claire L, Castro, Erika, Kouyos, R.D., Günthard, H F, Kaiser, R., Brun-Vezinet, Francoise, Jansen, K, Schuurman, R., Brun-Vezinet, F, Jansen, Klaus, Noguera-Julian, M., Bellecave, P, Schultze, Anna, Michalik, C, Kaiser, R, Masquelier, Bernard, Di Giallonardo, F, Schuurman, R, Däumer, M., Günthard, Huldrych F, Cozzi-Lepri, Alessandro, Masquelier, B, Brun-Vezinet, F., Aitken, Sue, Aitken, S, Paredes, R., Noguera-Julian, Marc, Geretti, Anna Maria, Bellecave, Pantxika, D'Arminio Monforte, A., Booth, C L, Di Giallonardo, F., Masquelier, B., Däumer, M, Kouyos, Roger D, Michalik, C., Castro, E, Furrer, H., Kouyos, R D, Metzner, K J, Schuurman, Rob, Jansen, K., Günthard, H.F., Noguera-Julian, M, Kaiser, Rolf, Paredes, R, Booth, C.L., Geretti, A.M., Schultze, A., Däumer, Martin, D'Arminio Monforte, A   +68 more
core   +1 more source

Harnessing novel cytidine deaminases from the animal kingdom for robust multiplexed base editing in rice

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1702-1712, May 2025.
Summary CRISPR‐Cas‐based cytosine base editors (CBEs) are prominent tools that perform site‐specific and precise C‐to‐T conversions catalysed by cytidine deaminases. However, their use is often constrained by stringent editing preferences for genomic contexts, off‐target effects and restricted editing windows.
Danyel Fernandes Contiliani, Simon Sretenovic, Micah Dailey, Man Zhou, Yanhao Cheng, Silvana Creste, Shunyuan Xiao, Yiping Qi   +7 more
wiley   +1 more source

Delving deeper into the pathogenesis and genomics of posttransplant diffuse large B‐cell lymphoma

HemaSphere, Volume 9, Issue 4, April 2025.
Abstract Posttransplant lymphoproliferative disorders (PTLDs) are a well‐known complication of solid organ transplantation and allogeneic hematopoietic stem cell transplantation. The diffuse large B‐cell lymphoma subtype (PT‐DLBCL) is the most frequent monomorphic PTLD and is associated with poor prognosis.
Flore Sneyers, Ana‐Lucía Rocha‐Iraizos, Vibeke K. J. Vergote, Daan Dierickx   +3 more
wiley   +1 more source

APOBEC3G-mediated Inhibition of Measles Virus Replication

, 2011
Das Masernvirus (MV) ist ein negativ-strängiges RNA-Virus aus der Familie der Paramyxovi-ridae und zählt immer noch zu den häufigsten Todesursachen bei Kindern in Entwicklungs-ländern.
Fehrholz, Markus
core   +2 more sources

Enrichment of G‐to‐U Substitution in SARS‐CoV‐2 Functional Regions and Its Compensation via Concurrent Mutations

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS‐CoV‐2 genomes. Among 10 012 SNVs, APOBEC‐mediated C‐to‐U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing‐related substitutions including (A > G, U > C, G > A).
Xierzhatijiang Sulaiman, Yan Han, Sheng Liu, Kailing Li, Marissa Shang, Lei Yang, Kenneth White, Yong Zang, Jikui Shen, Jun Wan   +9 more
wiley   +1 more source

Vpu and BST2: still not there yet?

Frontiers in Microbiology, 2012
Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV-1 replication and are widely accepted as ‘restriction factors’.
Kei eSato, Peter eGee, Yoshio eKoyanagi, Yoshio eKoyanagi   +3 more
doaj   +1 more source

Bird's eye view of natural products for the development of new anti‐HIV agents: Understanding from a therapeutic viewpoint

Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 441-457, March 2025.
Development of pharmaceutical drugs to cure HIV is crucial due to the current widespread epidemic. Nucleosides are the most effective anti‐HIV drugs, but their high toxicity and drug resistance limit their use. This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.
Md. Al Amin, Mohamed H. Nafady, Mehrukh Zehravi, Sherouk Hussein Sweilam, Kusuma Praveen Kumar, M. Akiful Haque, Aziz Unnisa, Laliteshwar Pratap Singh, Mohammed Sayeed, Mohammed Ali Alshehri, Irfan Ahmad, Talha Bin Emran, Md. Zia Uddin   +12 more
wiley   +1 more source

Functions, structure, and read-through alternative splicing of feline APOBEC3 genes [PDF]

, 2008
Background Over the past years a variety of host restriction genes have been identified in human and mammals that modulate retrovirus infectivity, replication, assembly, and/or cross-species transmission. Among these host-encoded restriction factors, the
Marion Battenberg, O'Brien, Stephen J., Hotz-Wagenblatt, Agnes, Battenberg, Marion, Thomas Beck, Sarah Chareza, O\u27Brien, Stephen J., Thielebein, Jens, Jörg Zielonka, Münk, Carsten, Cichutek, Klaus, Beck, Thomas W., Zielonka, Jörg, Chareza, Sarah, Bravo, Ignacio G., Beck, Thomas, Jens Thielebein, Klaus Cichutek, Ignacio G Bravo, Löchelt, Martin, Martin Löchelt, Carsten Münk, Agnes Hotz-Wagenblatt, Yuhki, Naoya, Stephen J O'Brien, Naoya Yuhki   +25 more
core   +1 more source

Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV

Clinical and Translational Medicine, Volume 15, Issue 3, March 2025.
Study involved 427 women with HIV. Identified 245 aberrant DNA methylation sites and 85 methylation regions in CD4+ T cells linked to the HIV‐1 reservoir. Highlighted genes are involved in viral replication, immune defence, and host genome integration. Findings suggest potential molecular targets for eradication strategies.
Ke Xu, Xinyu Zhang, Kesava Asam, Bryan C. Quach, Grier P. Page, Deborah Konkle‐Parker, Claudia Martinez, Cecile D. Lahiri, Elizabeth F. Topper, Mardge H. Cohen, Seble G. Kassaye, Jack DeHovitz, Mark H. Kuniholm, Nancie M. Archin, Amir Valizadeh, Phyllis C. Tien, Vincent C. Marconi, Dana B. Hancock, Eric O. Johnson, Bradley E. Aouizerat   +19 more
wiley   +1 more source

The role of VIF in overcoming the APOBEC3G block to HIV-1 replication [PDF]

This project focuses on the Virus Infectivity Factor protein of HIV-1 and its relief of the block to virus replication exerted by the APOBEC3G component of the innate immune response.
Kulkarni, Anurag
core