Results 71 to 80 of about 6,750 (198)
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source
A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G
Biology, 2012 APOBEC3G is the best known of several DNA cytosine deaminases that function to inhibit the replication of parasitic genetic elements including the lentivirus HIV.
Hiroshi Matsuo +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang +12 more
wiley +1 more source
Immunology, Volume 177, Issue 2, Page 299-316, February 2026.We utilised long‐read Nanopore sequencing to characterise the transcriptome of ferret cell lines stimulated with IFN‐α as well as nasal turbinates from ferrets infected with influenza A virus. We identified novel genes and isoforms and observed elongation of poly(A) tails in the ribosome and Coronavirus Disease‐19 pathways in response to IFN‐α ...
Rubaiyea Farrukee +7 more
wiley +1 more source
The Interaction between HIV-1 Gag and APOBEC3G [PDF]
Journal of Biological Chemistry, 2004 APOBEC3G, a member of an RNA/DNA cytidine deaminase superfamily, has been identified as a cellular inhibitor of HIV-1 infectivity, possibly through the dC to dU deamination of the first minus strand cDNA synthesized during reverse transcription. Virions incorporate APOBEC3G during viral assembly in non-permissive cells, and this incorporation is ...
Shan, Cen +5 more
openaire +2 more sources
Frontiers in Immunology, 2018 Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family members are cytidine deaminases that play crucial roles in innate responses to retrovirus infection.
Daniela A. Covino +9 more
doaj +1 more source
Análise de possíveis fatores relacionados à resistência ao HIV em parceiros soronegativos de casais HIV-sorodiscordantes da região da Grande Florianópolis [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2014.Atualmente, existem diversos relatos de indivíduos que se expuseram ao HIV e não
Santos, Iris Mattos
core
Drug Design, Development and Therapy, 2020 A-Long Cui,1,* Wen-Fang Sun,1,2,* Zhao-Jin Zhong,1 Jie Jin,1 Si-Tu Xue,1 Shuo Wu,1,2 Yu-Huan Li,1,2 Zhuo-Rong Li1 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s ...
Cui AL +7 more
doaj
Insights into the motif preference of APOBEC3 enzymes. [PDF]
PLoS ONE, 2014 We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT.
Diako Ebrahimi +2 more
doaj +1 more source
APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas
Immunity, Inflammation and Disease, Volume 13, Issue 7, July 2025.The results of this study suggest that high expression of APOBEC3C is associated with poor prognosis in glioma and may affect immune regulation. Knocking down APOBEC3C can inhibit the invasion and migration abilities of glioma cells. In addition, APOBEC3C can regulate the activation of the NF‐κB signaling pathway, which is expected to be a target for ...
Chao Zhang +6 more
wiley +1 more source