Results 91 to 100 of about 6,750 (198)
87. APOBEC3G and Immunity to Retroviruses
Molecular Therapy, 2004 APOBEC3G is capable of providing a cellular defense against retroviruses by deaminating deoxycytidine to deoxyuridine in the first strand of nascent retroviral cDNA. However, this defense can be counteracted by the HIV virion-infectivity factor (Vif), which targets APOBEC3G for degradation by the proteasome.
openaire +1 more source
Dual effect of APOBEC3G on Hepatitis B virus
Journal of General Virology, 2007 G to A hypermutation of Hepatitis B virus (HBV) and retroviruses appears as a result of deamination activities of host APOBEC proteins and is thought to play a role in innate antiviral immunity. Alpha and gamma interferons (IFN-α and -γ) have been reported to upregulate the transcription of APOBEC3G, which is known to reduce the replication of HBV.
Chiemi, Noguchi +13 more
openaire +2 more sources
Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells
Genome Biology, 2019 Background Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon.
Shraddha Sharma +9 more
doaj +1 more source
European Journal of Immunology, Volume 55, Issue 3, March 2025.The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV‐1 by primary dendritic cells. Virus is internalised into tetraspanin‐rich compartments, which leads to efficient HIV‐1 transmission to target cells. These results provide insight into how microbiota directly affect HIV‐1 uptake thereby altering HIV‐1 ...
Marleen Y. van Smoorenburg +5 more
wiley +1 more source
Rhesus macaque APOBEC3G genotype frequencies.
, 2013 Rhesus macaque APOBEC3G genotype frequencies.
Michael Letko (383232) +6 more
core +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Natural Resistance to HIV Infection: Role of Immune Activation
Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.High and low immune activation have been proposed as a possible explanation in HIV‐1 resistance. This review focuses on the most relevant evidence supporting each perspective. ABSTRACT Introduction Although repeated exposure to HIV‐1 can result in infection, some individuals remain seronegative without clinical or serologic evidence of infection; these
María M. Naranjo‐Covo +4 more
wiley +1 more source
Nature Communications, 2017 APOBEC3G inhibits HIV-1 viral replication via catalytic and non-catalytic processes. Here the authors show that APOBEC3G binds single-stranded DNA as an active deaminase monomer, subsequently forming catalytic-inactive dimers that block reverse ...
Michael Morse +5 more
doaj +1 more source
Cancer Communications, Volume 45, Issue 9, Page 1123-1127, September 2025.
Hyungtai Sim +4 more
wiley +1 more source
Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance
Heliyon, 2019 The APOBEC3 enzymes can induce mutagenesis of HIV-1 proviral DNA through the deamination of cytosine. HIV-1 overcomes this restriction through the viral protein Vif that induces APOBEC3 proteasomal degradation.
Nazanin Mohammadzadeh +5 more
doaj +1 more source