Results 81 to 90 of about 5,264 (176)

Cell‐type‐specific expression analysis of liver transcriptomics with clinical parameters to decipher the cause of intrahepatic inflammation in chronic hepatitis B

iMeta, Volume 3, Issue 4, August 2024.
This study integrates liver bulk transcriptomic data, single‐cell sequencing data, and clinical data to analyze the factors that induce hepatic inflammation in chronic hepatitis B from a multi‐omics perspective by Bayesian regression. Macrophages secrete chemokines like CCL20 and CXCL8 to recruit immune‐exhausted T lymphocytes (CTLA4, TIGIT) into liver
Jun Wang, Qian Li, Yuanwang Qiu, Simo Kitanovski, Chen Wang, Chenxia Zhang, Fahong Li, Xiaoguang Li, Zhenfeng Zhang, Lihua Huang, Jiming Zhang, Daniel Hoffmann, Mengji Lu, Hongzhou Lu   +13 more
wiley   +1 more source

Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G

Nature Communications, 2017
APOBEC3G inhibits HIV-1 viral replication via catalytic and non-catalytic processes. Here the authors show that APOBEC3G binds single-stranded DNA as an active deaminase monomer, subsequently forming catalytic-inactive dimers that block reverse ...
Michael Morse, Ran Huo, Yuqing Feng, Ioulia Rouzina, Linda Chelico, Mark C. Williams   +5 more
doaj   +1 more source

Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance

Heliyon, 2019
The APOBEC3 enzymes can induce mutagenesis of HIV-1 proviral DNA through the deamination of cytosine. HIV-1 overcomes this restriction through the viral protein Vif that induces APOBEC3 proteasomal degradation.
Nazanin Mohammadzadeh, Robin P. Love, Richard Gibson, Eric J. Arts, Art F.Y. Poon, Linda Chelico   +5 more
doaj   +1 more source

Dual effect of APOBEC3G on Hepatitis B virus

Journal of General Virology, 2007
G to A hypermutation of Hepatitis B virus (HBV) and retroviruses appears as a result of deamination activities of host APOBEC proteins and is thought to play a role in innate antiviral immunity. Alpha and gamma interferons (IFN-α and -γ) have been reported to upregulate the transcription of APOBEC3G, which is known to reduce the replication of HBV.
Chiemi, Noguchi, Nobuhiko, Hiraga, Nami, Mori, Masataka, Tsuge, Michio, Imamura, Shoichi, Takahashi, Yoshifumi, Fujimoto, Hidenori, Ochi, Hiromi, Abe, Toshiro, Maekawa, Hiromi, Yatsuji, Kotaro, Shirakawa, Akifumi, Takaori-Kondo, Kazuaki, Chayama   +13 more
openaire   +2 more sources

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.

PLoS Biology, 2004
Host genomes have adopted several strategies to curb the proliferation of transposable elements and viruses. A recently discovered novel primate defense against retroviral infection involves a single-stranded DNA-editing enzyme, APOBEC3G, that causes ...
Sara L Sawyer, Michael Emerman, Harmit S Malik   +2 more
doaj   +1 more source

High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity

Retrovirology, 2009
Human APOBEC3G is an antiretroviral protein that was described to act via deamination of retroviral cDNA. However, it was suggested that APOBEC proteins might act with antiviral activity by yet other mechanisms and may also possess RNA deamination ...
Münk Carsten, Flory Egbert, Ehrhardt Christina, Hofmann Henning, Schmolke Mirco, Pauli Eva-K, Ludwig Stephan   +6 more
doaj   +1 more source

APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts

PLoS Pathogens, 2008
APOBEC3G (A3G) is a host cytidine deaminase that, in the absence of Vif, restricts HIV-1 replication and reduces the amount of viral DNA that accumulates in cells. Initial studies determined that A3G induces extensive mutation of nascent HIV-1 cDNA during reverse transcription.
Bishop, K.N., Verma, M, Kim, E.-Y., Wolinsky, S.M., Malim, M.H.   +4 more
openaire   +5 more sources

Human APOBEC3G incorporation into murine leukemia virus particles

Virology, 2005
The human APOBEC3G protein exhibits broad antiretroviral activity against a variety of retroviruses. It is packaged into viral particles and executes its antiviral function in the target cell. The packaging of APOBEC3G into different viral particles requires a mechanism that confers this promiscuity.
Kremer, Melanie, Bittner, Alexandra, Schnierle, Barbara S.   +2 more
openaire   +2 more sources

APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso.

PLoS ONE, 2016
Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from
Tegwinde Rebeca Compaore, Serge Theophile Soubeiga, Abdoul Karim Ouattara, Dorcas Obiri-Yeboah, Damehan Tchelougou, Mamoudou Maiga, Maleki Assih, Cyrille Bisseye, Didier Bakouan, Issaka Pierre Compaore, Augustine Dembele, Jeremy Martinson, Jacques Simpore   +12 more
doaj   +1 more source

A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR

Retrovirology, 2009
Background Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infection under natural conditions ...
Zhou Tao, Han Yanxing, Dang Ying, Wang Xiaojun, Zheng Yong-Hui   +4 more
doaj   +1 more source